肝糖异生及其在2型糖尿病中的作用研究进展  

Research progress of hepatic gluconeogenesis and its role in type 2 diabetes mellitus

作　　者：脱伟旺 张朝宁[1] 陈瑞 刘聪聪 余臣祖[1] TUO Weiwang;ZHANG Chaoning;CHEN Rui;LIU Congcong;YU Chenzu(Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000

出　　处：《临床医学研究与实践》2024年第18期191-194,共4页Clinical Research and Practice

基　　金：2022年度甘肃中医药大学科学研究与创新基金项目(No.2022KCZD-2)。

摘　　要：2型糖尿病(T2DM)的主要特征是胰岛素抵抗(IR),其表现是抑制肝糖输出的效应减弱、肝糖异生异常表达。糖异生主要在肝脏中发生,其正常转运保证了机体的血糖处于正常稳态水平。本文综述了肝糖异生及其调控过程、肝糖异生在T2DM发病及治疗中的作用研究进展,以期为临床治疗T2DM提供参考。The main feature of type 2 diabetes mellitus(T2DM)is insulin resistance(IR),which is characterized by decreased effect of inhibiting hepatic glucose output and abnormal expression of hepatic gluconeogenesis.Gluconeogenesis mainly occurs in the hepar,and its normal transport ensures that the body's blood glucose is at a normal steady-state level.This article reviews the research progress of hepatic gluconeogenesis and its regulation process,and the role of hepatic gluconeogenesis in the pathogenesis and treatment of T2DM,in order to provide reference for clinical treatment of T2DM.

关 键 词：肝脏 糖异生 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]