2010—2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析  

Trends in abnormal glucose and lipid metabolism among newly treated HIV-infected patients and age-period-co⁃hort model analysis in Guangzhou,2010-2021

作　　者：尚萌琳 谢今朝 王旭 刘聪[2] 钟海丹[2] 杜佩珊[2] 李全敏[2] 蔡卫平[2] 李凌华[2] 顾菁[1] SHANG Menglin;XIE Jinzhao;WANG Xu;LIU Cong;ZHONG Haidan;DU Peishan;LI Quanmin;CAI Weiping;LI Linghua;GU Jing(School of Public Health,Sun Yat-sen University,Guangzhou 510000,China;Infectious Disease Center,Guangzhou Eighth People′s Hospital)

机构地区：[1]中山大学公共卫生学院,广东广州510000 [2]广州市第八人民医院感染病中心

出　　处：《华南预防医学》2024年第3期246-250,254,共6页South China Journal of Preventive Medicine

基　　金：“十三五”国家科技重大专项(2018ZX10715004)。

摘　　要：目的分析2010—2021年广州市初治HIV感染者糖脂代谢异常患病率的变化,探讨性别、年龄、时期、队列因素的影响。方法基于广州市第八人民医院2010—2021年16454例初治HIV感染者数据,采用Joinpoint回归模型分析糖代谢异常、甘油三酯代谢异常、胆固醇代谢异常的患病率变化趋势,采用年龄-时期-队列模型分析患病率变化的影响因素。结果16454例初治HIV感染者中,平均年龄(36.78±12.07)岁,男性13783例(83.8%)。2010—2021年期间初治HIV感染者糖代谢异常(AAPC=-2.4%,95%CI:-5.31%~0.50%,P=0.103)、甘油三酯代谢异常(APC=AAPC=-4.13%,95%CI:-7.59%~-0.54%,P=0.029)、胆固醇代谢异常(APC=AAPC=-13.47%,95%CI:-16.03%~-10.84%,P<0.001)患病率整体均呈下降趋势,女性脂代谢异常患病率高于男性。年龄-时期-队列模型结果显示,糖代谢异常、甘油三酯代谢异常的患病率在40~50岁最高,胆固醇代谢异常患病率随年龄增大逐渐下降;糖脂代谢异常的患病率随时期整体呈下降趋势;较早出生队列的人群糖脂代谢异常的患病率较高。结论近年来初治HIV感染者糖脂代谢异常负担整体降低,但仍应加强对糖代谢异常的防控。女性、中老年群体、较早的感染者是糖脂代谢异常的高危群体。Objective To analyze the changes in the prevalence of abnormal glucose and lipid metabolism among newly treated HIV-infected patients in Guangzhou from 2010 to 2021,and explore the influence of gender,age,period,and cohort factors.Methods Based on the treatment data of 16454 newly treated HIV-infected patients at Guangzhou Eighth People′s Hospital from 2010 to 2021,the trends in the prevalence of abnormal glucose,triglyceride,and cholesterol metabolism were analyzed by using Joinpoint regression,and the influencing factors of prevalence change were analyzed by using age-period-cohort model.Results Among the 16454 newly treated HIV-infected patients,the mean age was(36.78±12.07)years old,and 13783(83.8%)were males.From 2010 to 2021,the prevalence of abnormal glucose metabolism(AAPC=-2.4%,95%CI:-5.31%-0.50%,P=0.103),abnormal triglyceride metabolism(APC=AAPC=-4.13%,95%CI:-7.59%--0.54%,P=0.029),and abnormal cholesterol metabolism(APC=AAPC=-13.47%,95%CI:-16.03%--10.84%,P<0.001)showed a downward trend.The prevalence of abnormal lipid metabolism in females was higher than that in males.The results of the age-period-cohort model showed that the prevalence of abnormal glucose metabolism and triglyceride metabolism was highest in the age of 40-50 years,the prevalence of abnormal cholesterol metabolism gradually declined with age;the prevalence of abnormal glucose and lipid metabolism showed an overall decreasing trend with the period;and the prevalence of abnormal glucose and lipid metabolism was higher in the population of the earlier birth cohort.Conclusions The overall burden of abnormal glucose and lipid metabolism among newly treated HIV-infected patients has decreased in recent years.However,there is a need to enhance the prevention and control measures for abnormal glucose metabolism.Females,middle-aged and older groups,and earlier infected individuals are at high risk for abnormal glucose and lipid metabolism.

关 键 词：抗病毒治疗 HIV 糖脂代谢异常 Joinpoint回归模型 年龄-时期-队列模型 

分 类 号：R195.4[医药卫生—卫生统计学]