安肠组方联合磷酸铝凝胶对宫颈癌放疗致放射性肠炎患者炎症因子、免疫功能以及肠道菌群的影响  

Effects of Anchang Formula Combined with Aluminium Phosphate Gel on Inflammatory Factors,Immune Function and Intestinal Flora in Patients with Radiation Enteritis Induced by Radiotherapy for Cervical Cancer

作　　者：孙月红 何新颖[1] 贾大鹏 杜强 胡婷婷 杨洪娟 孙云川[1] SUN Yue-Hong;HE Xin-Ying;JIA Da-Peng;DU Qiang;HU Ting-Ting;YANG Hong-Juan;SUN Yun-Chuan(Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou 061000 Hebei,China)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《广州中医药大学学报》2024年第5期1160-1166,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(编号:2022245)。

摘　　要：【目的】探究安肠组方(由仙鹤草、生地榆、茯苓、白头翁、白术、炒白芍等中药组成)联合磷酸铝凝胶对宫颈癌放疗后所致放射性肠炎患者炎症因子、免疫功能以及肠道菌群的影响。【方法】将78例宫颈癌放疗后所致放射性肠炎患者随机分为联合组41例和参照组37例。参照组给予磷酸铝凝胶治疗,联合组给予安肠组方联合磷酸铝凝胶治疗,疗程为15 d。观察2组患者治疗前后中医证候积分、血清白细胞介素2(interleukin-2,IL-2)、降钙素原(procalcitonin,PCT)、T淋巴细胞亚群CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平及肠道菌群的变化情况,并评价2组患者的临床疗效。【结果】(1)疗效方面,治疗15 d后,联合组的总有效率为90.24%(37/41),参照组为70.27%(26/37),组间比较,联合组的临床疗效明显优于参照组(P<0.05)。(2)中医证候方面,治疗后,2组患者的黏液脓血便、腹泻、里急后重、腹痛等中医证候积分均较治疗前降低(P<0.05),且联合组的降低幅度均明显优于参照组(P<0.01)。(3)炎症因子方面,治疗后,2组患者的血清IL-2、PCT水平均较治疗前降低(P<0.05),且联合组的降低幅度均明显优于参照组(P<0.01)。(4)免疫功能方面,治疗后,2组患者的T淋巴细胞亚群CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高(P<0.05),CD8^(+)水平均较治疗前降低(P<0.05),且联合组对CD4^(+)、CD4^(+)/CD8^(+)水平的升高幅度及对CD8^(+)水平的降低幅度均明显优于参照组(P<0.01)。(5)肠道菌群方面,治疗后,2组患者的乳酸杆菌、双歧杆菌、大肠埃希菌水平均较治疗前升高(P<0.05),且联合组的升高幅度均明显优于参照组(P<0.01)。【结论】安肠组方联合磷酸铝凝胶对宫颈癌放疗后所致放射性肠炎患者进行治疗,能显著改善患者的临床症状,减轻炎症反应,提高免疫功能,平衡肠道菌群,临床疗效显著。To observe the effect of Anchang Formula(mainly composed of Agrimoniae Herba,Sanguisorbae Radix,Poria,Pulsatillae Radix,Atractylodis Macrocephalae Rhizoma,and fried Paeoniae Radix Alba)combined with Aluminum Phosphate Gel on inflammatory factors,immune function and intestinal flora in patients with radiation enteritis caused by radiotherapy for cervical cancer.Methods Seventy-eight patients with radiation enteritis caused by radiotherapy for cervical cancer were randomly divided into combined group(41 cases)and reference group(37 cases).The reference group was treated with Aluminum Phosphate Gel,and the combined group was treated with Anchang Formula combined with Aluminum Phosphate Gel.The course of treatment for the two groups lasted for 15 days.The changes of traditional Chinese medicine(TCM)syndrome scores,serum interleukin 2(IL-2),procalcitonin(PCT),T lymphocyte subsets CD4^(+),CD8^(+),CD4^(+)/CD8^(+)levels and intestinal flora in the two groups were observed before and after treatment.After treatment,the clinical efficacy of the two groups was evaluated.Results(1)After 15 days of treatment,the total effective rate of the combined group was 90.24%(37/41),and that of the reference group was 70.27%(26/37).The intergroup comparison showed that the clinical efficacy of the combined group was significantly superior to that of the reference group(P<0.05).(2)After treatment,the scores of TCM symptoms of mucopurulent bloody stool,diarrhea,tenesmus and abdominal pain in the two groups were lower than those before treatment(P<0.05),and the decrease in the combined group was significantly superior to that in the reference group(P<0.01).(3)After treatment,the levels of serum inflammatory factors of IL-2 and PCT in the two groups were lower than those before treatment(P<0.05),and the decrease in the combined group was more obvious than that in the reference group(P<0.01).(4)After treatment,the levels of immune function indicators of T lymphocyte subsets CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those b

关 键 词：安肠组方 磷酸铝凝胶 宫颈癌 放疗 放射性肠炎 炎症因子 免疫功能 肠道菌群 

分 类 号：R273.373[医药卫生—中西医结合]