2型糖尿病视网膜病变患者中医证型分布及其与血清炎症因子及脂联素水平的相关性研究  

Study on the Distribution of Traditional Chinese Medicine Syndromes in Patients with Type 2 Diabetic Retinopathy and Its Correlation with Serum Inflammatory Factors and Adiponectin Levels

作　　者：吴红云[1] 袁振轩 陈芳[2] 叶炜 胡莉群[1] 曾宪忠[3] 徐哲 WU Hong-Yun;YUAN Zhen-Xuan;CHEN Fang;YE Weil;HU Li-Qun;ZENG Xian-Zhong;XU Zhe(Dept.of Ophthalmology,Ganzhou People's Hospital,Ganzhou 341000 Jiangxi,China;Dept.of Traditional Chinese Medicine,Ganzhou People's Hospital,Ganzhou 341000 Jiangxi,China;Dept.of Endocrinology,Ganzhou People's Hospital,Ganzhou 341000 Jiangxi,China)

机构地区：[1]江西省赣州市人民医院眼科,江西赣州1341000 [2]江西省赣州市人民医院中医科,江西赣州341000 [3]江西省赣州市人民医院内分泌科,江西赣州341000

出　　处：《广州中医药大学学报》2024年第6期1371-1379,共9页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：江西省中医药管理局科技计划项目(编号:2022B293)。

摘　　要：【目的】探讨2型糖尿病视网膜病变(type 2 diabetic retinopathy,T2DR)的中医证型分布及其与血清炎症因子、脂联素(APN)水平的相关性,为T2DR的中医辨证分型提供客观依据。【方法】采用横断面病例对照研究方法,选择2022年9月至2023年3月在江西省赣州市人民医院眼科诊断为T2DR的患者共42例84眼,观察T2DR患者眼底荧光血管造影(FFA)分期与中医辨证分型的关系,分析不同中医证型与血清炎症因子及APN水平的关系以及不同FFA分期的血清炎症因子及APN水平差异,探讨T2DR患者各变量与不同中医证型之间的相关性。【结果】(1)42例T2DR患者中,男性27例,女性15例,平均年龄为(54.0±12.0)岁;其中,肝肾亏虚、目络失养证14例(33.3%),阴精不足、燥热内生证15例(35.7%),气阴两虚、络脉瘀阻证9例(21.4%),阴阳两虚、血瘀痰凝证4例(9.5%),脾失健运、水湿阻滞证0例(0.0%)。(2)肝肾亏虚、目络失养证患者中双眼眼底FFA分期≥4期[增殖期糖尿病视网膜病变(PDR)]者占78.6%(11/14),阴精不足、燥热内生证患者占73.3%(11/15),气阴两虚、络脉瘀阻证患者和阴阳两虚、血瘀痰凝证患者均占100%(9/9;4/4),但组间比较,差异无统计学意义(P=0.272)。(3)42例T2DR患者中,有35例(83.3%)患者的肿瘤坏死因子α(TNF-α)、28例(68.3%)患者的C反应蛋白(CRP)、38例(90.5%)患者的糖化血红蛋白(HbA1c)水平均高于正常值;但不同FFA分期患者的血清炎症因子TNF-α、CRP、白细胞介素6(IL-6)、血管内皮生长因子(VEGF)及APN、HbA1c水平比较,差异均无统计学意义(P>0.05);同时,不同中医证型的血清APN、TNF-α、CRP、IL-6、VEGF水平比较,差异也均无统计学意义(P>0.05)。(4)相比肝肾亏虚、目络失养证患者,阴阳两虚、血瘀痰凝证患者的眼部病程较短,两者的相关性接近差异有统计学意义(r=-0.467,P=0.051);相比阴精不足、燥热内生证患者,阴阳两虚、血瘀痰凝证患者的CRP水平较高(r=0.592,Objective To investigate the distribution of traditional Chinese medicine(TCM)syndromes in patients with type 2 diabetic retinopathy(T2DR)and to explore the correlation of TCM syndromes with serum inflammatory factors and adiponectin(APN)levels,so as to provide evidence for TCM syndrome differentiation of T2DR.Methods A cross-sectional case-control study was conducted in 42 patients(involving 84 eyes)diagnosed as T2DR in the Department of Ophthalmology,Ganzhou People’s Hospital from September 2022 to March 2023.The correlation between fundus fluorescein angiography(FFA)staging and TCM syndrome differentiation in patients with T2DR was explored.The relationship between TCM syndrome types and serum levels of inflammatory factors and APN,as well as the differences in serum inflammatory factors and APN levels of the patients with various FFA stages were analyzed.The correlation between each variable and TCM syndrome types in patients with T2DR was investigated.Results(1)Among the 42 patients with T2DR,27 cases were male and 15 cases were female,and their age averaged(54.0±12.0)years old.Among them,14 cases(33.3%)were differentiated as liver-kidney deficiency with malnutrition of eye collateral syndrome,15 cases(35.7%)were differentiated as yin-essence deficiency with internal dry-heat syndrome,9 cases(21.4%)were differentiated as qi-yin deficiency with collateral stasis and obstruction syndrome,4 cases(9.5%)were differentiated as yin-yang deficiency with blood stasis and phlegm coagulation syndrome,and none case(0.0%)was differentiated as spleen dysfunction and water-damp obstruction syndrome.(2)FFA staging showed that FFA staging≥4[i.e.,having proliferative diabetic retinopathy(PDR)]was found in 78.6%(11/14)of the patients with liver-kidney deficiency with malnutrition of eye collaterals syndrome,73.3%(11/15)of the patients with yin-essence deficiency with internal dry-heat syndrome,100%(9/9)of the patients with qi-yin deficiency with collateral stasis and obstruction syndrome,and 100%(4/4)of the patients with

关 键 词：2型糖尿病视网膜病变 中医辨证分型 炎症因子 脂联素 相关性 

分 类 号：R276.7[医药卫生—中医五官科学]