黄力辨治冠心病经皮冠状动脉介入术后再发心绞痛的用药规律探讨  

Exploration on the Medication Rules of HUANG Li in Treating Recurrent Angina Pectoris After Percutaneous Coronary Intervention for Coronary Heart Disease

作　　者：陶诗怡 汤献文 于林童 杨德爽 姚睿祺 张兰鑫 吴佳芸 黄力(指导)[3] TAO Shi-Yi;TANG Xian-Wen;YU Lin-Tong;YANG De-Shuang;YAO Rui-Qi;ZHANG Lan-Xin;WU Jia-Yun;HUANG Li(Beijing University of Chinese Medicine,Beijing 100029,China;Shenzhen Longgang Hospital of Beijing University of Chinese Medicine,Shenzhen 518000 Guangdong,China;China-Japan Friendship Hospital,Beijing 100029,China;Shenzhen Nanshan Chinese Medicine Hospital,Shenzhen 518000 Guangdong,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学深圳医院(龙岗),广东深圳川518000 [3]中日友好医院,北京100029 [4]深圳市南山区中医院,广东深圳518000 [5]中国中医科学院广安门医院,北京100053

出　　处：《广州中医药大学学报》2024年第6期1598-1606,共9页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药管理局科研课题(编号:20232146)。

摘　　要：【目的】运用数据挖掘方法分析黄力教授辨治冠心病经皮冠状动脉介入术(PCI)后再发心绞痛的用药规律。【方法】收集黄力教授于中日友好医院门诊治疗冠心病PCI术后再发心绞痛的有效病例的处方资料。采用SPSS Statistics 26.0软件和SPSS Modeler 18.0软件对处方中药进行频次统计、功效和性味归经分析、关联规则分析、聚类分析和因子分析。【结果】共得到中药处方344首,涉及中药209味,累计用药频次为5874次。以出现频次居前30位的中药为高频中药,其中使用频次>100次的中药依次为黄芪、川芎、葛根、红景天、三七、茯苓、降香、白术、莪术、三棱、山药、陈皮、法半夏、党参、甘草等。高频中药的功效归类以活血化瘀药和补气药最多。药物的药性以温性、平性和寒性为主,药味偏甘、辛、苦,归经以归脾经、肺经、肝经为主。挖掘得到关联规则30条,聚类组合5类,公因子11组。【结论】黄力教授治疗心血管疾病常以气、血、水理论为指导,尤重气机升降;认为气虚血瘀为PCI术后再发心绞痛的基本病机,治疗多以益气活血化瘀立法,五脏同调、寒温并用,辅以益气健脾、化痰利水、安神宁心、行气散结、破血逐瘀之品。Objective To explore the medication rules of Professor HUANG Li for the treatment of recurrent angina pectoris after percutaneous coronary intervention(PCI)for coronary heart disease by data mining method.Methods The prescriptions for effective cases of recurrent angina pectoris after PCI for coronary heart disease treated by Professor HUANG Li in the outpatient department of China-Japan Friendship Hospital were collected.SPSS Statistics 26.0 software and SPSS Modeler 18.0 software were used for frequency statistics,analysis of the therapeutic actions,properties,flavors and meridian tropism of the prescribed herbs as well as association rule analysis,cluster analysis and factor analysis of the herbs.Results A total of 344 Chinese medicine prescriptions were obtained,involving 209 herbs,with a cumulative frequency of 5874 times.The top 30 Chinese medicinals were named as the high-frequency Chinese medicines,and the herbs with the frequency over 100 times in descending order were Astragali Radix,Chuanxiong Rhizoma,Puerariae Lobatae Radix,Rhodiolae Crenulatae Radix et Rhizoma,Notoginseng Radix et Rhizoma,Poria,Dalbergiae Odoriferae Lignum,Atractylodis Macrocephalae Rhizoma,Curcumae Rhizoma,Spargani Rhizoma,Dioscoreae Rhizoma,Citri Reticulatae Pericarpium,Pinelliae Rhizoma Praeparatum,Codonopsis Radix,and Glycyrrhizae Radix et Rhizoma.The highfrequency Chinese medicinals were mostly classified as blood-activating and stasis-resolving drugs and qireplenishing drugs.The medicinal properties of the drugs were characterized by being warm,mild,or cold,the flavors were predominated by being sweet,pungent or bitter,and the medicinals usually had the meridian tropism of the spleen,lung and liver meridians.A total of 30 association rules were mined out,cluster analysis yielded 5 herbal groups,and factor analysis yielded 1l groups of common factors.Conclusion For the treatment of cardiovascular diseases,Professor HUANG Li follows the theory of qi,blood and water,and especially pays more attention to the ascending and descendin

关 键 词：冠心病 经皮冠状动脉介入术 心绞痛 气血水理论 益气活血化瘀 黄芪 川芎 葛根 红景天 黄力 

分 类 号：R256.22[医药卫生—中医内科学] R541.4[医药卫生—中医学]