不同剂量更昔洛韦治疗新生儿先天性巨细胞病毒感染的疗效  

Comparison of Efficacy and Safety of Different Doses of Ganciclovir in the Treatment of Neonatal Congenital Cytomegalovirus Infection

作　　者：郭佳佳[1] 霍婉莹 雷冰 张彦华[1] GUO Jiajia;HUO Wanying;LEI Bing;ZHANG Yanhua(The Third Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052)

机构地区：[1]郑州大学第三附属医院,河南郑州450052

出　　处：《深圳中西医结合杂志》2024年第7期94-97,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:比较不同剂量更昔洛韦治疗新生儿先天性巨细胞病毒感染的疗效及安全性。方法:选取郑州大学第三附属医院2019年2月至2022年2月期间收治的50例新生儿先天性巨细胞病毒感染患儿,依据不同剂量更昔洛韦用药分为小剂量组(6.0 mg·kg^(-1))、大剂量组(7.5 mg·kg^(-1)),各25例,比较两组患儿临床症状评分、肝功能、病毒学检查结果、临床疗效、副作用发生情况。结果:两组患儿治疗后发热、呕吐腹泻、黄疸、肝大、原始反射异常评分均低于治疗前,血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)水平及人类巨细胞病毒的脱氧核糖核酸(CMV-DNA)、基因拷贝数变异的免疫球蛋白G(CNV-IgG)、基因拷贝数变异的免疫球蛋白M(CNV-IgM)阳性率均低于治疗前,差异具有统计学意义(P<0.05),但两组组间比较,差异均无统计学意义(P>0.05);小剂量组患儿的副作用发生率低于大剂量组,差异具有统计学意义(P<0.05)。两组患儿总有效率比较,差异均无统计学意义(P>0.05)。结论:大剂量和小剂量更昔洛韦治疗新生儿先天性巨细胞病毒感染的疗效相当,但小剂量安全性更高。Objective To compare the efficacy and safety of different doses of ganciclovir in the treatment of congenital cytomegalovirus infection in newborns.Methods Fifty newborns with congenital cytomegalovirus infection admitted to the Third Affiliated Hospital of Zhengzhou University from February 2019 to February 2022 were selected.According to different doses of ganciclovir,they were divided into a low-dose group(6.0 mg·kg^(-1))and a high-dose group(7.5 mg·kg^(-1)),with 25 cases in each group.Clinical symptom scores,liveRfunction,virological examination results,clinical efficacy,and incidence of side effects were compared between the two groups.Results AfteRtreatment,the scores of fever,vomiting,diarrhea,jaundice,hepatomegaly,and abnormal primitive reflex of the two groups of children were loweRthan before treatment.The levels of serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),human cytomegalovirus deoxyribonucleic acid(CMV-DNA),copy numbeRvariant immunoglobulin G(CNV-IgG),and copy numbeRvariant immunoglobulin M(CNV-IgM)were loweRthan those before treatment,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference between the two groups(P>0.05);The incidence of side effects in the low-dose group was loweRthan that in the high-dose group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total effective rate between the two groups(P>0.05).Conclusion The therapeutic effects of high-dose and low-dose ganciclovir in the treatment of congenital cytomegalovirus infection in newborns are comparable,but the safety of low-dose is higher.

关 键 词：先天性巨细胞病毒感染 更昔洛韦 用药剂量 新生儿 

分 类 号：R722.13[医药卫生—儿科]