蛋白琥珀酸铁与硫酸亚铁治疗小儿缺铁性贫血的临床有效性及安全性研究  

Study on the Clinical Efficacy and Safety of Iron Protein Succinylate and Ferrous Sulfate in the Treatment of Iron Deficiency Anemia in Children

作　　者：李静 LI Jing(Children Health Care Department of Jinxian Maternal and Child Health Hospital,Jinxian 331700,Jiangxi,China)

机构地区：[1]进贤县妇幼保健院儿童保健科,江西进贤331700

出　　处：《医学信息》2024年第12期111-114,共4页Journal of Medical Information

摘　　要：目的观察蛋白琥珀酸铁与硫酸亚铁治疗小儿缺铁性贫血的临床有效性及安全性。方法选取2021年1月-2023年1月在我院诊治的60例缺铁性贫血小儿为研究对象,采用随机数字表法分为对照组和观察组,各组30例。对照组采用硫酸亚铁治疗,观察组采用蛋白琥珀酸铁治疗,比较两组治疗总有效率、血常规指标[红细胞计数(RBC)、血红蛋白(Hb)、红细胞平均血红蛋白(MCH)]、血清铁、血清铁蛋白、血清转铁蛋白水平、不良反应发生率,以及复发率。结果观察组治疗总有效率为93.33%,高于对照组的83.33%(P<0.05);两组治疗后RBC、Hb、MCH水平均高于治疗前,且观察组高于对照组(P<0.05);两组治疗后血清铁、血清铁蛋白水平均高于治疗前,血清转铁蛋白均低于治疗前,且观察组血清铁、血清铁蛋白水平高于对照组,血清转铁蛋白低于对照组(P<0.05);观察组不良反应发生率为6.67%,低于对照组的20.00%(P<0.05);随访3个月,观察组复发率为3.33%,低于对照组的13.33%(P<0.05)。结论蛋白琥珀酸铁与硫酸亚铁治疗小儿缺铁性贫血均具有一定的疗效,但是相对而言蛋白琥珀酸铁治疗效果确切,可提高治疗总有效率,显著改善血常规指标和铁代谢指标,且不良反应发生率、复发率低,可作为临床治疗小儿缺铁性贫血的首选药物。Objective To observe the clinical efficacy and safety of iron protein succinylate and ferrous sulfate in the treatment of iron deficiency anemia in children.Methods Sixty children with iron deficiency anemia diagnosed and treated in our hospital from January 2021 to January 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 30 children in each group.The control group was treated with ferrous sulfate,and the observation group was treated with iron protein succinylate.The total effective rate,blood routine indexes[red blood cell count(RBC),hemoglobin(Hb),mean corpuscular hemoglobin(MCH)],serum iron,serum ferritin,serum transferrin levels,incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 83.33%in the control group(P<0.05).The levels of RBC,Hb and MCH in the two groups after treatment were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of serum iron and serum ferritin in the two groups were higher than those before treatment,and the levels of serum transferrin were lower than those before treatment,meanwhile the levels of serum iron and serum ferritin in the observation group were higher than those in the control group,and the levels of serum transferrin were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 6.67%,which was lower than 20.00%in the control group(P<0.05).After 3 months of follow-up,the recurrence rate of the observation group was 3.33%,which was lower than 13.33%of the control group(P<0.05).Conclusion Iron protein succinylate and ferrous sulfate have certain curative effects in the treatment of iron deficiency anemia in children,but relatively speaking,iron protein succinylate has a definite therapeutic effect,which can

关 键 词：蛋白琥珀酸铁 硫酸亚铁 小儿缺铁性贫血 临床有效性 安全性 

分 类 号：R725.5[医药卫生—儿科]