睾酮检测在儿童阴茎发育不良中的诊断价值  

Diagnostic Value of Testosterone Detection in Children with Hypoplasic Penis

作　　者：周春红 梁金根 ZHOU Chun-hong;LIANG Jin-gen(Department of Clinical Laboratory,Xiushui County Maternal and Child Health Hospital,Xiushui 332400,Jiangxi,China;Department of Pediatrics,Xiushui County Hospital of Traditional Chinese Medicine,Xiushui 332400,Jiangxi,China)

机构地区：[1]修水县妇幼保健院检验科,江西修水332400 [2]修水县中医院儿科,江西修水332400

出　　处：《医学信息》2024年第12期123-125,129,共4页Journal of Medical Information

摘　　要：目的探讨睾酮检测在儿童阴茎发育不良诊断中的价值。方法选取2020年1月-2022年8月修水县妇幼保健院诊治的66例阴茎发育不良儿童作为观察组,另选取同期在修水县妇幼保健院体检健康的66名儿童作为对照组,比较两组性激素水平(睾酮、硫酸脱氢表雄酮、促黄体生成素、促卵泡刺激素)、阴茎和睾丸体征,并分析不同检测指标诊断对儿童阴茎发育不良的诊断敏感度、特异度。结果观察组睾酮、硫酸脱氢表雄酮、促黄体生成素及促卵泡刺激素水平均低于对照组(P<0.05);观察组阴茎长度、阴茎直径均小于对照组(P<0.05);观察组儿童睾丸长径、睾丸横径小于对照组(P<0.05);睾酮+硫酸脱氢表雄酮+促黄体生成素+促卵泡刺激素检测诊断儿童阴茎不良的敏感度、特异度均高于其他指标单独诊断,且睾酮单独检测诊断敏感度、特异度高于其他单独指标诊断(P<0.05)。结论儿童阴茎发育不良与睾酮、硫酸脱氢表雄酮、促黄体生成素及促卵泡刺激素水平密切相关,在结合临床指征的同时,可通过联合检测以上指标进行儿童阴茎发育不良的诊断,以提高诊断准确率,为临床有效治疗提供参考。Objective To explore the value of testosterone detection in the diagnosis of hypoplasic penis in children.Methods Sixty-six children with hypoplasic penis diagnosed and treated in Xiushui County Maternal and Child Health Hospitall from January 2020 to August 2022 were selected as the observation group,and 66 healthy children who underwent physical examination in Xiushui County Maternal and Child Health Hospital during the same period were selected as the control group.The levels of sex hormones(testosterone,dehydroepiandrosterone sulfate,luteinizing hormone,follicle-stimulating hormone),penile and testicular signs were compared between the two groups,and the diagnostic sensitivity and specificity of different detection indicators for the diagnosis of penile dysplasia in children were analyzed.Results The levels of testosterone,dehydroepiandrosterone sulfate,luteinizing hormone and follicle stimulating hormone in the observation group were lower than those in the control group(P<0.05).The penis length and penis diameter in the observation group were smaller than those in the control group(P<0.05).The long diameter and transverse diameter of testis in the observation group were smaller than those in the control group(P<0.05).The sensitivity and specificity of testosterone+dehydroepiandrosterone sulfate+luteinizing hormone+follicle stimulating hormone in the diagnosis of poor penis in children were higher than those of other indicators alone,and the sensitivity and specificity of testosterone alone were higher than those of other indicators alone(P<0.05).Conclusion Children with hypoplasic penis is closely related to the levels of testosterone,dehydroepiandrosterone sulfate,luteinizing hormone and follicle stimulating hormone.Combined with clinical indications,the above indicators can be combined to diagnose children's hypoplasic penis,so as to improve the diagnostic accuracy and provide reference for clinical effective treatment.

关 键 词：睾酮 阴茎发育不良 促黄体生成素 促卵泡刺激素 

分 类 号：R726.9[医药卫生—儿科]