达格列净联合二甲双胍治疗初诊2型糖尿病临床观察  

Clinical Observation of Dapagliflozin Combined with Metformin in the Treatment of Newly-Diagnosed Diabetes Mellitus Type 2

作　　者：张丽萍 袁伟芳 代丽丽 ZHANG Liping;YUAN Weifang;DAI Lili(Funan County People's Hospital,Fuyang,Anhui,China 236300)

机构地区：[1]安徽省阜阳市阜南县人民医院,安徽阜阳236300

出　　处：《中国药业》2024年第12期85-88,共4页China Pharmaceuticals

基　　金：安徽省高校自然科学研究项目[KJ2021A0855]。

摘　　要：目的探讨达格列净联合二甲双胍治疗初诊2型糖尿病(T2DM)的临床疗效。方法选取医院2021年9月至2022年7月收治的初诊T2DM患者110例,按治疗方案的不同分为对照组和观察组,各55例。两组患者均予盐酸二甲双胍片口服,观察组患者加服达格列净片。两组均治疗6个月。结果观察组总有效率为90.91%,显著高于对照组的74.55%(P<0.05)。与对照组比较,观察组患者治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白水平及胰岛素抵抗指数均显著降低,空腹胰岛素水平及胰岛素敏感指数(ISI)均显著升高;血清血管性血友病因子、内皮素水平均显著降低;超氧化物歧化酶、谷胱甘肽过氧化物酶水平均显著升高,丙二醛水平显著降低;健康调查简表(SF-36)评分显著升高(P<0.05)。两组不良反应发生率无显著差异(P>0.05)。结论达格列净联合二甲双胍治疗初诊T2DM,能有效提高患者的ISI,降低其血管内皮因子和氧化应激水平。Objective To investigate the clinical efficacy of dapagliflozin combined with metformin in the treatment of newly-diagnosed diabetes mellitus type 2(T2DM).Methods A total of 110 patients with newly-diagnosed T2DM admitted to the hospital from September 2021 to July 2022 were selected and divided into the control group and the observation group based on different treatment regimens,with 55 cases in each group.The patients in the two groups were treated with Metformin Hydrochloride Tablets orally,on this basis,the patients in the observation group were treated with Dapagliflozin Tablets.Both groups were treated for six months.Results The total effective rate in the observation group was 90.91%,which was significantly higher than 74.55%in the control group(P<0.05).Compared with those in the control group,the fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)and homeostasis model assessment of insulin resistance(HOMA-IR)in the observation group significantly decreased after treatment,the fasting insulin(FINS)level and insulin sensitivity index(ISI)significantly increased;the serum von Willebrand Factor(vWF)and endothelin(ET)levels significantly decreased;the superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)levels significantly increased,the malondialdehyde(MDA)level significantly decreased;the 36-item Short-Form(SF-36)score significantly increased(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dapagliflozin combined with metformin can effectively improve the ISI,decrease the vascular endothelial factor and oxidative stress levels of patients with newly-diagnosed T2DM.

关 键 词：达格列净 初诊 2型糖尿病 胰岛素敏感指数 血管内皮功能 氧化应激 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R587.1[医药卫生—药学]