胸腺五肽治疗带状疱疹有效性和安全性Meta分析  

Effectiveness and Safety of Thymopentin in the Treatment of Herpes Zoster:A Meta-Analysis

作　　者：王雨 刘宇 杨佳丹[1] 王红梅[1] 宋捷[1] WANG Yu;LIU Yu;YANG Jiadan;WANG Hongmei;SONG Jie(The First Affiliated Hospital of Chongqing Medical University,Chongqing,China 400010)

机构地区：[1]重庆医科大学附属第一医院,重庆400010

出　　处：《中国药业》2024年第12期110-115,共6页China Pharmaceuticals

基　　金：重庆医科大学未来医学青年创新团队发展支持计划[W0014]。

摘　　要：目的为临床使用胸腺五肽治疗带状疱疹提供证据支持。方法收集中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普(VIP)、万方(WanFang)、PubMed、Embase、The Cochrane Library数据库中有关胸腺五肽治疗带状疱疹的随机对照试验,检索时限为各数据库起自建库至2023年11月。采用Cochrane手册中的RoB 2.0工具对文献进行质量评价,采用RevMan 5.4软件进行Meta分析,并采用GRADE工具评价结局指标的证据等级。结果共纳入文献7篇,均为中文文献,涉及患者471例。Meta分析结果显示,试验组疼痛缓解时间[MD=-1.62,95%CI(-2.29,-0.96),P<0.001],疼痛消退时间[MD=-3.07,95%CI(-3.74,-2.39),P<0.001],有效率[RR=1.13,95%CI(1.04,1.22),P=0.002],不良反应发生率[RR=0.41,95%CI(0.19,0.91),P=0.03]均显著优于对照组,但两组结痂时间无显著差异[MD=-1.12,95%CI(-2.44,0.20),P=0.10]。结局指标的证据等级均为低质量或极低质量。结论胸腺五肽治疗带状疱疹的有效性和安全性均优于单纯抗病毒治疗,但目前结论证据等级均较低,对临床实践缺乏强有力的支撑,需要更多高质量研究证实。Objective To provide evidence for the clinical use of thymopentin in the treatment of herpes zoster.Methods Randomized controlled trials of thymopentin in the treatment of herpes zoster in the CNKI,CBM,VIP,WanFang,PubMed,Embase and The Cochrane Library from the inception of each database to November 2023 were collected.The RoB 2.0 tool of the Cochrane manual was used to evaluate the quality of studies,the RevMan 5.4 software was used for Meta-analysis,and the GRADE tool was used for evidence quality assessment of outcome indicators.Results A total of seven studies were included,all in Chinese,involving 471 patients.The Meta-analysis showed that the pain relief time[MD=-1.62,95%CI(-2.29,-0.96),P<0.001],pain disappearance time[MD=-3.07,95%CI(-3.74,-2.39),P<0.001],effective rate[RR=1.13,95%CI(1.04,1.22),P=0.002],and incidence of adverse reactions[RR=0.41,95%CI(0.19,0.91),P=0.03]in the test group were significantly better than those in the control group,but the scabbing time in the test group was similar to that in the control group[MD=-1.12,95%CI(-2.44,0.20),P=0.10].The quality of evidence was low or very low.Conclusion Thymopentin therapy is more effective and safer than simple antiviral therapy for herpes zoster,but the evidence for current conclusion is relatively low,lacking robust support for clinical practice and requiring more high-quality researches to confirm.

关 键 词：胸腺五肽 带状疱疹 有效性 安全性 META分析 证据质量 

分 类 号：R969.4[医药卫生—药理学]