MicroRNA调控CLDN1功能的研究进展  

Research progress on regulation of microRNA on function of CLDN1

作　　者：符娟 杨忠海 严志强 刘化进 Fu Juan;Yang Zhonghai;Yan Zhiqiang;Liu Huajin(Medical College,Anhui University of Science and Technology,Huainan,Anhui 232000,China;Central Laboratory,Central Hospital of Fengxian District,Shanghai 201400,China;Department of Cardiology,Central Hospital of Fengxian District,Shanghai 201400,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232000 [2]上海市奉贤区中心医院中心实验室,上海201400 [3]上海市奉贤区中心医院心内科,上海201400

出　　处：《齐齐哈尔医学院学报》2024年第11期1069-1073,共5页Journal of Qiqihar Medical University

摘　　要：microRNA(微小RNA,miRNA)是一类非编码RNA中(既非蛋白质进行编码形成的RNA)的一种,长约有20~25个核苷酸长的小分子RNA。CLDN1(紧密连接蛋白1,Claudin-1)是紧密连接蛋白家族中的一员,其含有211个氨基酸残基来组成大约为23 kDa的蛋白。CLDN1主要存在于细胞连接中,形成细胞间连接部位,并形成屏障功能。研究表明,miRNA可以调节编码CLDN1蛋白基因的翻译过程,并影响其稳定性来调节功能,影响呼吸、消化、肿瘤、中枢神经、循环以及皮肤屏障等众多系统疾病的发生发展过程中。本文就miRNA对CLDN1的调节作用以及与相关疾病发生发展的关系进行综述,为防治与CLDN1改变相关的疾病提供新的见解及其研究思路。MicroRNA(miRNA)is a type of non-coding RNA,approximately 20-25 nucleotides in length,which does not encode proteins.Claudin-1(CLDN1),a member of the tight junction protein family,is synthesized by 211 amino acid residues,with a molecular weight of approximately 23 kDa.CLDN1 predominantly exists in cell junctions,forming intercellular connections and providing barrier functions.Studies have shown that miRNA can modulate the translation and stability of the CLDN1 gene,influencing the development of various systemic diseases including respiratory,digestive,tumorigenic,central nervous,circulatory,and dermatological disorders.This review summarizes the regulatory role of miRNA on CLDN1 and its association with the development of related diseases,offering novel insights and research avenues for the prevention and treatment of diseases associated with CLDN1 alterations.

关 键 词：MIRNA CLDN1 紧密连接蛋白1 屏障功能 

分 类 号：R34[医药卫生—基础医学]