依帕司他片+硫辛酸注射液治疗糖尿病周围神经病变的临床效果  

Clinical Effect of Epalrestat Tablets+Lipoic Acid Injection in the Treatment of Diabetic Peripheral Neuropathy

作　　者：陈丽媛 林富祥 韦春姣 CHEN Liyuan;LIN Fuxiang;WEI Chunjiao(Department of Endocrinology,Guangxi Medical University Kaiyuan Langdong Hospital,Nanning,Guangxi Zhuang Autonomous Region,530000 China;Catheterization Room,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi Zhuang Autonomous Region,530000 China)

机构地区：[1]广西医大开元埌东医院内分泌科,广西南宁530000 [2]广西医科大学第一附属医院导管室,广西南宁530000

出　　处：《糖尿病新世界》2024年第7期183-186,共4页Diabetes New World Magazine

摘　　要：目的探讨依帕司他片+硫辛酸在糖尿病周围神经病变患者中的治疗效果。方法选取2022年9月—2023年9月广西医科大学第一附属医院接受治疗的98例糖尿病周围神经病变患者为研究对象,依据随机数表法分为对照组(49例)和观察组(49例)。对照组予以硫辛酸注射液治疗,观察组联合依帕司他片治疗。治疗3个月后对比两组疗效、生化指标、不良反应发生情况。结果观察组治疗总有效率(97.96%)高于对照组(81.63%),差异有统计学意义(χ^(2)=7.127,P=0.008)。观察组治疗后各项血液生化指标均低于对照组,差异有统计学意义(P均<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论依帕司他片+硫辛酸用于糖尿病周围神经病变患者中效果显著,对患者的临床症状起到明显改善作用,且可以改善血液生化水平,未发生严重不良反应。Objective To explore the therapeutic effect of epalrestat tablets+lipoic acid in patients with diabetic pe-ripheral neuropathy.Methods A total of 98 diabetic peripheral neuropathy patients treated in the First Affiliated Hos-pital of Guangxi Medical University from September 2022 to September 2023 were selected as the study objects,and they were divided into control group(49 cases)and observation group(49 cases)according to random number table method.The control group was treated with lipoic acid injection,and the observation group was treated with epalrestat tablets.After 3 months of treatment,the efficacy,biochemical indexes and adverse reactions of the two groups were compared.Results The total effective rate of observation group(97.96%)was higher than that of control group(81.63%),and the difference was statistically significant(χ^(2)=7.127,P=0.008).After treatment,all blood biochemical indexes in the observation group were lower than those in the control group,and the differences were statistically sig-nificant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Epalrestat tablets+lipoic acid used in patients with diabetic peripheral neuropathy is effective,play a significant role in improving the clinical symptoms of patients,and can improve blood biochemical levels,no serious adverse reactions.

关 键 词：依帕司他片 硫辛酸注射液 糖尿病周围神经病变 神经功能 

分 类 号：R587.1[医药卫生—内分泌]