可溶性程序性死亡受体-1及其配体和干扰素-γ在急性冠脉综合症患者血清中的表达特征和临床意义  

Characteristics and clinical significance of serum soluble programmed cell death receptor-1/ligand-1 and interferon-γexpression in patients with acute coronary syndrome

作　　者：牛红霞 毛月然 陈琦琪 胥俊越 董静 王振 杨彦娜 张明 Hongxia Niu;Yueran Mao;Qiqi Chen;Junyue Xu;Jing Dong;Zhen Wang;Yanna Yang;Ming Zhang(Department of Emergency,Capital Medical University Electric Power Teaching Hospital,State Grid Corporation of China,Beijing Electric Power Hospital,Beijing 100073,China;Department of Laboratory Medicine,Capital Medical University Electric Power Teaching Hospital,State Grid Corporation of China,Beijing Electric Power Hospital,Beijing 100073,China;Physical Examination Department,Capital Medical University Electric Power Teaching Hospital,State Grid Corporation of China,Beijing Electric Power Hospital,Beijing 100073,China;Department of Cardiovascular Medicine,Capital Medical University Electric Power Teaching Hospital,State Grid Corporation of China,Beijing Electric Power Hospital,Beijing 100073,China)

机构地区：[1]首都医科大学电力教学医院、国家电网公司北京电力医院急诊科,北京100073 [2]首都医科大学电力教学医院、国家电网公司北京电力医院检验科,北京100073 [3]首都医科大学电力教学医院、国家电网公司北京电力医院体检科,北京100073 [4]首都医科大学电力教学医院、国家电网公司北京电力医院心血管内科,北京100073

出　　处：《中华卫生应急电子杂志》2024年第1期10-15,共6页Chinese Journal of Hygiene Rescue(Electronic Edition)

摘　　要：目的对急性冠脉综合征患者血清中sPD-1/L1和干扰素-γ的表达特征及临床意义初步探讨。方法本研究回顾性纳入2020年11月至2022年10月北京电力医院急诊科收治的73例患者,将所有患者分为对照组和冠心病组(分为慢性冠脉疾病组和急性冠脉综合征组)。急性冠状动脉综合征组患者32例,其中男性19例,女性13例;年龄54~84岁,平均(69.09±14.97)岁。慢性冠脉疾病组患者21例,其中男性8例,女性13例;年龄65~83岁,平均(74.24±8.60)岁。对照组20例,其中男性13例,女性7例;年龄58~73岁,平均(65.70±7.39)岁,采用酶联免疫吸附试验法(ELISA)检测3组患者血清sPD-1及sPD-L1、IFN-γ水平。结果3组患者间血清免疫标志物对比分析可知,IL-18、IFN-γ、sPD-1/L1水平比较,差异有统计学意义(P<0.05),ACS组及慢性冠脉疾病组患者IL-18表达水平显著高于对照组,差异有统计学意义(P<0.01);慢性冠脉疾病组患者IFN-γ表达水平显著高于ACS组及对照组(P<0.05);sPD-1/L1在ACS组和慢性冠脉疾病组患者表达显著高于对照组人群,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,ACS组患者血清IFN-γ表达与sPD-1(r=0.922,P<0.01)及L1(r=0.922,P<0.01)呈正相关。结论ACS患者中sPD-1/L1与IFN-γ之间存在一定的关系,ACS患者IFN-γ的释放增加,进而可能导致sPD-1/L1的表达增加,而sPD-1/L1表达的增加可能在ACS的免疫调节中发挥重要作用。Objective To investigate the expression characteristics and clinical significance of serum sPD-1/L1 and interferon-γexpression in patients with acute coronary syndrome.Methods This study retrospectively included 73 patients admitted to the emergency department of Beijing Electric Power Hospital from November 2020 to October 2022.All patients were divided into a control group and a coronary heart disease group(divided into chronic coronary disease group and acute coronary syndrome group).32 patients in the acute coronary syndrome group,including 19 males and 13 females;Age range from 54 to 84 years old,with an average of(69.09±14.97)years old.There are 21 patients in the chronic coronary disease group,including 8 males and 13 females;Age range from 65 to 83 years old,with an average of(74.24±8.60)years old.20 cases in the control group,including 13 males and 7 females;Age range from 58 to 73 years old,with an average of(65.70±7.39)years old.Enzyme linked immunosorbent assay(ELISA)was used to detect serum sPD-1,sPD-L1,and IFN in three groups of patients-γHorizontal.Results The comparative analysis of serum immune markers among the three groups showed that there were significant differences in the levels of IL-18,IFN-γThe comparative analysis of serum immune markers among the three groups showed that there were sigisease group were significantly higher than those in the control group(P<0.01),and the expression levels of IFN-an those in the control group(showed that there were significant differences in the levels of IL-18,IFN-ol group(P<0.05).The expression of L1 in the ACS group and the chronic coronary disease group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that serum IFN-p was significantly higher thorrelated with sPD-1(r=0.922,P<0.01)and L1(r=0.922,P<0.01)in the ACS group.Conclusion There is a certain relationship between sPD-1/L1 and IFN-N-p was significantly higher than that in the control group,and

关 键 词：急性冠脉综合征 可溶性程序性死亡受体-1 可溶性程序性死亡配体-1 干扰素-Γ 

分 类 号：R541.4[医药卫生—心血管疾病]