艾滋病合并侵袭性真菌病相关免疫重建炎症综合征  

Invasive fungal diseases-related immune reconstitution inflammatory syndrome in AIDS patients

作　　者：张沁枝 郭朋乐 李凌华[1] Zhang Qinzhi;Guo Pengle;Li Linghua(Infectious Disease Center,Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou 510440,China)

机构地区：[1]广州医科大学附属市八医院感染病中心,广州510440

出　　处：《国际流行病学传染病学杂志》2024年第2期120-124,共5页International Journal of Epidemiology and Infectious Disease

基　　金：广东省医学基金项目(A2023333);广州市科技计划(2023A03J0793、2023A03J0794、202201020276);2021—2023年广州市医学重点学科(病毒性传染病)。

摘　　要：侵袭性真菌病(invasive fungal disease, IFD)是AIDS患者常见的机会性感染, 部分患者启动抗逆转录病毒治疗后出现IFD相关免疫重建炎症综合征(immune reconstitution inflammatory syndrome, IRIS), 引起强烈炎症反应, 使患者病情再度恶化。IFD相关IRIS临床特征不典型, 常导致诊断及治疗延迟, 但其发生机制尚不明确。本文拟对AIDS合并IFD相关IRIS流行情况、发生机制、危险因素、临床特征及诊疗方案相关研究进展进行综述, 以提高对该病的认识和诊治水平。Invasive fungal disease(IFD)is a common opportunistic infection among AIDS patients,with some patients developing IFD-related immune reconstitution inflammatory syndrome(IRIS)following the initiation of antiretroviral therapy(ART).IFD-related IRIS triggers a robust inflammatory response,leading to a deterioration of the patient's condition.The clinical manifestations of IFD-related IRIS are often ambiguous,resulting in delayed diagnosis and treatment,yet its underlying mechanisms remain unclear.In this article,the prevalence,pathogenesis,risk factors,clinical features,and therapeutic strategies of IFD-related IRIS in AIDS patients are summarized,aiming to improve the knowledge and optimize the diagnosis and treatment strategies.

关 键 词：获得性免疫缺陷综合征 免疫重建炎症综合征 侵袭性真菌病 糖皮质激素 

分 类 号：R512.91[医药卫生—内科学] R519[医药卫生—临床医学]