1990—2019年中国糖尿病肾病患病流行特征分析  

Analysis of epidemic characteristics of diabetic nephropathy in China from 1990 to 2019

作　　者：农晓鑫 韦盼盼 李畅 黄晓凤 邓树嵩 NONG Xiao-xin;WEI Pan-pan;LI Chang;HUANG Xiao-feng;DENG Shu-song(School of Public Health and Management,Youjiang Medical College for Nationalities,Baise,Guangxi 533000,China)

机构地区：[1]右江民族医学院公共卫生与管理学院,广西百色533000

出　　处：《现代预防医学》2024年第11期1950-1955,共6页Modern Preventive Medicine

摘　　要：目的了解中国糖尿病肾病患病流行特征,为糖尿病肾病的防治策略和措施提供科学依据。方法选取全球健康数据交换数据库GBD 2019年的数据,收集1990—2019年中国糖尿病肾病患病数据,描述各年份标准化患病率、年龄别患病率的特征及趋势,利用Joinpoint回归模型分析中国糖尿病肾病患病率的时间变化趋势。结果中国1型糖尿病肾病全人群和女性年龄标准化患病率趋势变化没有转折点,APC=AAPC,均呈上升趋势,全人群整体年均增长1.02%(95%CI:0.87%~1.17%),女性整体年均增长1.21%(95%CI:1.08%~1.35%);男性趋势变化转折点为1994、2011和2017年,整体年均增长0.56%(95%CI:0.20%~0.92%);年龄别<20岁年龄组患病率呈下降趋势(AAPC=-0.71%~-0.12%),≥20岁年龄组呈上升趋势(AAPC=1.06%~3.99%),差异均具有统计学意义(P<0.05)。中国2型糖尿病肾病全人群、男性和女性年龄标准化患病率趋势变化转折点均为1995、2000、2005、2010和2015年,全人群整体年均下降0.15%(95%CI:-0.17%~-0.12%),男性整体年均下降0.12%(95%CI:-0.16%~-0.09%),女性整体年均下降0.18%(95%CI:-0.22%~-0.15%)。年龄别15~19岁、55~59岁、≥75岁以上年龄组患病率在1990—2019年间呈上升趋势(AAPC=0.05%~0.30%),20~39岁各年龄组呈下降趋势(AAPC=-1.59%~-0.36%),差异均具有统计学意义(P<0.05)。中国2型糖尿病肾病其他年龄组的变化差异无统计学意义(P>0.05)。结论1990—2019年中国糖尿病肾病流行趋势依然严峻,应对糖尿病及其并发症加大重视。尤其是全面关注女性患病率一直比男性高、2型糖尿病肾病患病率在15~39岁、55~59岁、≥75岁群体持续增长以及1型糖尿病肾病患病率在≥20岁的年龄组逐渐增长的人群,及时调整相应的对策。Objective To understand the epidemic characteristics of diabetic nephropathy in China and to provide scientific basis for the prevention and treatment of diabetic nephropathy.Methods Data from the Global Burden of Disease(GBD)database in 2019 was selected to collect data on the incidence of diabetic nephropathy in China from 1990 to 2019.The characteristics and trends of standardized incidence rates and age-specific incidence rates in each year were described,and the Joinpoint regression model was used to analyze the temporal trend of the incidence rate of diabetic nephropathy in China.Results There was no turning point in the trend of age-standardized prevalence of type 1 diabetic nephropathy in the whole population and women in China,and the annual percent change(APC)equaled the average annual percent change(AAPC),showing an upward trend.The average annual growth rate of the whole population was 1.02%(95%CI:0.87%-1.17%),and that of women as a whole was 1.21%(95%CI:1.08%-1.35%).The turning point of male trend was in 1994,2011,and 2017,with an overall average annual growth of 0.56%(95%CI:0.20%-0.92%).The incidence rates for age groups under 20 years old showed a decreasing trend(AAPC=-0.71%to-0.12%),while those aged 20 and above showed an increasing trend(AAPC=1.06%to 3.99%),all with statistical significance(P<0.05).The standardized incidence rates of type 2 diabetic nephropathy for the whole population,males,and females in China had turning points in 1995,2000,2005,2010,and 2015,with an overall annual decrease of 0.15%(95%CI:-0.17%to-0.12%)for the whole population,0.12%for males(95%CI:-0.16%to-0.09%),and 0.18%for females(95%CI:-0.22%to-0.15%).Conclusion The epidemic trend of diabetic nephropathy in China from 1990 to 2019 is still grim,and more attention should be paid to diabetes and its complications.In particular,the prevalence rate of women has been higher than that of men,and the prevalence rate of type 2 diabetic nephropathy in the age group of 15-39 years old,55-59 years old,and≥75 years old,as well as

关 键 词：糖尿病肾病 标准化患病率 年龄别患病率 Joinpoint回归模型 趋势分析 

分 类 号：R587.1[医药卫生—内分泌]