精液质量与不同精子发育期大气污染物暴露水平相关性分析  

Analysis of correlation between semen quality and exposure level of air pollutants in different stages of sperm development

作　　者：蔡可 王莉[1,2] 崔馨月[1] 白淘 王立言 CAI Ke;WANG Li;CUI Xin-yue;BAI Tao;WANG Li-yan(Department of Pediatric Health,School of Public Health,Shanxi Medical University,Taiyuan,Shanxi 030001,China;不详)

机构地区：[1]山西医科大学公共卫生学院儿少卫生教研室,山西太原030001 [2]煤炭环境致病与防治教育部重点实验室 [3]山西医科大学第一医院病理科,山西太原030001 [4]山西医科大学汾阳医学院

出　　处：《现代预防医学》2024年第11期1968-1974,2007,共8页Modern Preventive Medicine

摘　　要：目的分析太原市大气污染物对男性精液质量及不同精子发育时期的影响。方法纳入2019年1月1日—12月31日就诊于山西医科大学第一医院生殖科的7614名男性为研究对象,记录其年龄、精液采集季节和精液参数等信息。同时收集6种大气污染物(SO_(2)、NO_(2)、CO、O_(3)、PM_(2.5)、PM10)监测数据,计算精子整个发育期(精液采集前0~90 d)和三个发育关键期(精液采集前0~9 d、10~14 d和70~90 d)的大气污染物暴露情况。采用非参数检验Mann-Whitney U检验比较精液参数合格组与不合格组之间数据差异。采用广义估计方程,探讨精子各发育时期内六种大气污染物对每个精子质量参数的影响。结果在精子整个发育时期,SO_(2)、NO_(2)、O_(3)和PM_(2.5)暴露浓度在正常精子形态合格与不合格分组中均有差异。精液采集前10~14 d,PM10暴露与精液体积(OR=1.245,95%CI:1.057~1.467)、精子浓度(OR=1.247,95%CI:1.027~1.514)、精子总数(OR=1.385,95%CI:1.167~1.643)、总活力(OR=1.236,95%CI:1.085~1.409)和前向运动(OR=1.207,95%CI:1.059~1.376)不合格呈正相关;O_(3)暴露与精子浓度(OR=1.250,95%CI:1.002~1.558;OR=1.173,95%CI:1.025~1.343)、精子总数(OR=1.255,95%CI:1.026~1.537;OR=1.218,95%CI:1.074~1.380)、正常精子形态(OR=1.295,95%CI:1.047~1.602;OR=1.229,95%CI:1.076~1.404)不合格呈正相关。结论在精子各发育阶段,大气污染物暴露均增加各精液参数不合格的风险,而关键窗口期集中于精液采集前10~14 d,即精子活力的发育阶段。PM10和O_(3)是影响太原市男性精子质量下降的主要生殖毒物,需引起关注。Objective To analyze the effects of air pollutants on male semen quality and different stages of sperm development in Taiyuan.Methods Totally 7614 men who were admitted to the Reproductive Department of the First Hospital of Shanxi Medical University from January 1 to December 31,2019 were enrolled.Their age,semen collection season,and semen parameters were recorded.At the same time,the monitoring data of six air pollutants(SO_(2),NO_(2),CO,O_(3),PM_(2.5),and PM_(10))were collected,and the exposure of air pollutants in the whole developmental period(0 to 90 days before semen collection)and three critical developmental periods(0-9 days,10-14 days,and 70-90 days)were calculated.Nonparametric Mann-Whitney U test was used to compare the data difference between qualified and unqualified semen parameters.The generalized estimation equation was used to explore the effects of six kinds of air pollutants on the quality parameters of each sperm at different stages of sperm development.Results During the whole period of sperm development,the exposure concentrations of SO_(2),NO_(2),O_(3),and PM_(2.5)were different between the qualified and unqualified groups of normal sperm morphology.The exposure to PM_(10)at 10 and 14 days before semen collection was positively correlated with semen volume(OR=1.245,95%CI:1.057-1.467),sperm concentration(OR=1.247,95%CI:1.027-1.514),total sperm count(OR=1.385,95%CI:1.167-1.643),total motility(OR=1.236,95%CI:1.085-1.409),and forward movement(OR=1.207,95%CI:1.059-1.376).The O_(3)exposure was positively correlated with sperm concentration(OR=1.250,95%CI:1.002-1.558;OR=1.173,95%CI:1.025-1.343),total sperm count(OR=1.255,95%CI:1.026-1.537;OR=1.218,95%CI:1.074-1.380),and normal sperm morphology(OR=1.295,95%CI:1.047-1.602;OR=1.229,95%CI:1.076-1.404).Conclusion Exposure to air pollutants increases the risk of unqualified semen parameters at all stages of sperm development,and the critical window period focuses on 10-14 days before semen collection,which is the developmental stage of sperm motility.

关 键 词：大气污染物 精液质量 PM_(10) O_(3) 关键窗口期 

分 类 号：R122[医药卫生—环境卫生学]