晕船对机体代谢的影响  

Effects of seasickness on metabolism

作　　者：孙文青 成思 于苹苹 荆柯 周琳 Sun Wenqing;Cheng Si;Yu Pingping;Jing Ke;Zhou Lin(Department of Laboratory Medicine,the Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Department of Laboratory Medicine,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Nursing Department,the Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China)

机构地区：[1]海军军医大学第二附属医院检验科,上海200003 [2]上海中医药大学附属曙光医院检验科,上海201203 [3]海军军医大学第三附属医院护理部,上海200438

出　　处：《中华航海医学与高气压医学杂志》2024年第2期215-218,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的观察晕船对机体代谢的影响。方法以35名海军舰艇部队官兵为研究对象,远航发生风浪后分为晕船组和非晕船组,测定风浪发生后第1天和第4天血清尿素、肌酐、尿酸以及丙氨酸氨基转移酶、碱性磷酸酶、总胆红素、直接胆红素、羟丁酸脱氢酶、乳酸脱氢酶、淀粉酶的变化。结果风浪后第1天晕船组较非晕船组血清尿素[(6.81±1.09)mmol/L vs.(5.85±0.83)mmol/L]、肌酐[(85.38±10.53)μmol/L vs.(77.85±6.50)μmol/L]、尿酸[(447.85±51.88)μmol/L vs.(381.00±50.69)μmol/L]明显上升(P<0.05);晕船组风浪后第4天较第1天血清尿素、肌酐、尿酸明显下降[(5.99±1.30)mmol/L vs.(6.81±1.09)mmol/L、(78.15±11.89)mmol/L vs.(85.38±10.53)mmol/L、(358.38±77.70)μmol/L vs.(447.85±51.88)μmol/L](P<0.01);晕船组风浪后第4天较第1天血清丙氨酸氨基转移酶、碱性磷酸酶明显下降(P<0.05);风浪后第1天晕船组较非晕船组血清总胆红素、直接胆红素、羟丁酸脱氢酶、乳酸脱氢酶、淀粉酶无明显差异(均P>0.05)。结论晕船对机体代谢指标有明显影响,表现为晕船开始时血清尿素、肌酐、尿酸明显上升,3 d后明显降低;血清丙氨酸氨基转移酶、碱性磷酸酶在晕船开始时无明显变化,3 d后明显下降;血清尿素和尿酸是影响晕船代谢的主要指标,晕船对血清胆红素、羟丁酸脱氢酶、乳酸脱氢酶、淀粉酶无明显影响。Objective To observe the impact of seasickness on metabolism.Methods A total of 35 servicemen aboard a naval ship were divided into seasickness group and non-seasickness group during a long voyage.The urea,creatinine,uric acid,alanine transaminase,alkaline phosphatase,total bilirubin,direct bilirubin,hydroxybutyrate dehydrogenase,lactic dehydrogenase,and amylase in the serum were detected on the first day and forth day after entering the rough sea,and the changes were compared and analyzed.Results On the first day after entering the rough sea,the urea[(6.81±1.09)mmol/L vs.(5.85±0.83)mmol/L],creatinine[(85.38±10.53)μmol/L vs.(77.85±6.50)μmol/L],and uric acid[(447.85±51.88)μmol/L vs.(381.00±50.69)μmol/L]in the seasickness group were significantly higher than those in the non-seasickness group(P<0.05);in the seasickness group,the urea,creatinine,and uric acid[(5.99±1.30)mmol/L vs.(6.81±1.09)mmol/L、(78.15±11.89)mmol/L vs.(85.38±10.53)mmol/L,(358.38±77.70)μmol/L vs.(447.85±51.88)μmol/L]on the fourth day were significantly lower than those on the first day(P<0.01),while the alanine transaminase and alkaline phosphatase on the fourth day were significantly lower than those on the first day.There was no significant difference in total bilirubin,direct bilirubin,hydroxybutyrate dehydrogenase,lactic dehydrogenase,and amylase between the seasickness group and the non-seasickness group on the first day after entering the rough sea.Conclusion Seasickness can significantly impact metabolic indicators of the body.Upon the onset of seasickness,the serum urea,creatinine,and uric acid significantly increased,but significantly decreased three days later.There was no significant change of alanine transaminase and alkaline phosphatase at the onset of seasickness,but these indicators decreased significantly after three days.Serum urea and uric acid are the main indicators of the impact of seasickness on metabolism;and seasickness has no significant effect on serum bilirubin,hydroxybutyrate dehydrogenase,lactic dehy

关 键 词：晕船 风浪 尿素 尿酸 碱性磷酸酶 

分 类 号：R832[医药卫生—航空、航天与航海医学]