慢性肾脏病患者左心室肥厚危险因素的研究进展  

Research progress on risk factors of left ventricular hypertrophy in patients with chronic kidney disease

作　　者：李巧玲 韦喆 LI Qiaoling;WEI Zhe(Graduate School,Youjiang Medical University for Nationalities,Guangxi,Baise 533000,China;Department of Nephrology,Hechi Hospital Affiliated to Youjiang Medical University for Nationalities,Guangxi,Hechi 547000,China)

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]右江民族医学院附属河池医院肾内科,广西河池547000

出　　处：《中国医药科学》2024年第10期48-51,110,共5页China Medicine And Pharmacy

摘　　要：左心室肥厚(LVH)是慢性肾脏病(CKD)患者中最常见的心肌损害,室间隔增厚是评估LVH的重要定量指标。导致CKD患者LVH的危险因素,包括高血压、糖尿病、容量超负荷、透析方式、贫血、继发性甲状旁腺功能亢进、营养不良、血脂代谢异常及慢性炎症反应等,这些因素互相影响,共同作用于心血管系统,导致CKD患者发生心脏结构及功能改变。目前新的危险因素如骨调节蛋白、成纤维细胞生长因子23,对CKD患者LVH的相关发病机制、治疗的研究仍尚少,将来仍需收集大样本量的研究进一步探讨,寻找对应靶点进行干预,改善CKD患者的预后。Left ventricular hypertrophy(LVH)is the most common myocardial damage in patients with chronic kidney disease(CKD),and ventricular septal thickening is an important quantitative index to evaluate LVH.The risk factors leading to LVH in CKD patients include hypertension,diabetes,volume overload,dialysis mode,anemia,secondary hyperparathyroidism,malnutrition,abnormal lipid metabolism and chronic inflammatory reaction,etc.These factors interact with each other and work together on the cardiovascular system,leading to changes in cardiac structure and function in CKD patients.At present,there are new risk factors such as N-terminal pro-B type natriuretic peptide(NT-proBNP),osteoprotegerin and fibroblast growth factor 23,but there are still few studies on the pathogenesis and treatment of LVH in CKD patients.In the future,it is necessary to collect a large number of samples for further study to find corresponding targets for intervention and improve the prognosis of CKD patients.

关 键 词：慢性肾脏病 左心室肥厚 室间隔 危险因素 

分 类 号：R692[医药卫生—泌尿科学]