铁基纳米颗粒在磁共振成像中的研究进展  

Research Progress of Iron-based Nanoparticles in Magnetic Resonance Imaging

作　　者：赵嘉驹 胡黎文 郭婷 ZHAO Jiaju;HU Liwen;GUO Ting(School of Medicine,South China University of Technology,Guangzhou 510006,China;School of Materials Science and Engineering,South China University of Technology,Guangzhou 510006,China)

机构地区：[1]华南理工大学医学院,广州510006 [2]华南理工大学材料科学与工程学院,广州510006

出　　处：《医学综述》2024年第14期1749-1755,共7页Medical Recapitulate

基　　金：国家自然科学基金(22205081)。

摘　　要：铁基纳米颗粒具有超顺磁性、低毒性、高磁化率等独特的物理、化学和高生物相容性的特点,是一类典型的磁共振成像(MRI)造影剂,包括磁性氧化铁纳米颗粒和超顺磁性氧化铁纳米颗粒两种。它能够与外加磁场产生局部磁矩,并引起局部磁场改变自旋方向,具有很好的对比度和信噪比,产生较高的MRI信号强度和对比度,能够提供清晰的图像。同时,铁基纳米颗粒具有较好的生物相容性和较低的细胞毒性,对人体安全性较高,特别是在MRI对肿瘤和炎症等疾病进行早期诊断和治疗时,在实现肿瘤协同精准治疗过程中发挥重要作用。随着铁基纳米颗粒合成技术的提高,医工多学科交叉融合可实现新型造影剂对靶点的精准定位和高分辨率成像,为疾病治疗和生物医学的发展做出巨大贡献。Iron-based nanoparticles with unique physical,chemical and high biocompatibility features such as superparamagnetism,low toxicity,and high magnetization rate are a representative class of magnetic resonance imaging(MRI)contrast agents,including two types of magnetic iron oxide nanoparticles and superparamagnetic iron oxide nanoparticles.It can generate local magnetic moments with external magnetic fields and cause the local magnetic field to change the direction of spin,with good contrast and signal-to-noise ratio,producing MRI signal strength and contrast,and providing clear images.Meanwhile,it has good biocompatibility and low cytotoxicity,and high safety for the human body,especially in the early diagnosis and treatment of diseases such as tumors and inflammation using MRI,playing an important role in achieving precise and synergistic treatment of tumors.With the improvement of iron-based nanoparticle synthesis technology,the interdisciplinary fusion of medical and engineering can achieve precise localization and high-resolution imaging of new contrast agents on targets,making a huge contribution to the disease treatment and development of biomedical science.

关 键 词：磁共振成像 铁基 纳米颗粒 磁性氧化铁 

分 类 号：R445.2[医药卫生—影像医学与核医学]