微生态制剂用于新生儿黄疸全静脉营养支持治疗对患儿免疫功能及营养状况的影响分析  

Effect of Microecological Preparation on Immune Function and Nutritional Status of Neonates with Jaundice Treated by Total Intravenous Nutrition

作　　者：黄月 Huangyue(Emergency Department,Xiangfu District First People’s Hospital,Kaifeng,Henan,475100,China)

机构地区：[1]祥符区第一人民医院·开封市第三人民医院急诊科,河南开封475100

出　　处：《黑龙江医学》2024年第11期1331-1333,共3页Heilongjiang Medical Journal

摘　　要：目的:观察微生态制剂在新生儿黄疸全静脉营养支持治疗中的应用效果及对患儿免疫功能、营养状况的影响。方法:选取2021年1月—2022年6月祥符区第一人民医院收治的123例新生儿黄疸患儿作为研究对象,采用抽签法将患儿分为观察组(62例)和对照组(61例)。两组患儿均统一实施全静脉营养支持治疗,观察组患儿采用微生态制剂辅助治疗,比较两组患儿治疗前后的免疫功能、营养状态,对所有患儿开展为期6个月短期随访,比较两组患儿随访期间的胃肠动力改善情况及预后情况。结果:治疗后,观察组患儿的免疫球蛋白(Ig)M、IgA、IgG等体液免疫指标,T淋巴细胞CD3^(+)、CD4^(+)、CD8^(+)等细胞免疫指标水平均高于对照组,血清总蛋白(TP)、白蛋白(ALB)、转铁蛋白(TRF)等营养指标水平高于对照组,差异有统计学意义(t=2.202、2.794、2.117、3.384、2.724、3.461、3.007、3.723、2.799,P<0.05);随访期间,观察组患儿治疗后1个月、3个月、6个月时的血胃泌素(GAS)均高于对照组,不良事件发生率为4.84%(3/62),低于对照组的14.75%(9/61),差异有统计学意义(χ^(2)=5.558,P<0.05)。结论:采用微生态制剂辅助新生儿黄疸的全静脉营养支持治疗可显著提升机体免疫功能,对改善患儿机体营养状态、促进胃肠动力恢复并降低不良事件发生风险均有积极意义。Objective:To observe the application effect of micro-ecological preparation in total intravenous nutrition support treatment of neonatal jaundice and its influence on immune function and nutritional status of children.Methods:123 cases of neonatal jaundice admitted to Xiangfu District First People’s Hospital from January 2021 to June 2022 were selected as the study subjects.The enrolled children were divided into observation group(62 cases)and control group(61 cases)by drawing lots.Both groups of children were treated with total intravenous nutrition support,and the observation group was treated with micro-ecological agents.The immune function and nutritional status of the two groups before and after treatment were compared.All children were followed up for a short period of 6 months to compare the improvement of gastrointestinal motility and prognosis during the follow-up period.Results:After treatment,the levels of humoral immune indexes,such as immunoglobulin(Ig)M,IgA,IgG,and cellular immune indexes,such as CD3^(+),CD4^(+) and CD8^(+) of T lymphocytes in the observation group were higher than those in the control group,and the levels of serum total protein(TP),albumin(ALB),transferrin(TRF)and other nutritional indexes were higher than those in the control group(t=2.202,2.794,2.117,3.384,2.724,3.461,3.007,3.723,2.799;P<0.05).During the follow-up period,the serum gastrin(GAS)in the observation group was higher than that in the control group 1,3 and 6 months after treatment,and the incidence of adverse events was 4.84%(3/62),which was lower than that in the control group[14.75%(9/61)],with statistically significant diffence(χ^(2)=5.558,P<0.05).Conclusion:The use of micro-ecological preparation assisted total intravenous nutrition support treatment for neonatal jaundice can significantly improve the immune function of the body,improve the nutritional status of children,promote the recovery of gastrointestinal motility,and reduce the risk of adverse events.

关 键 词：新生儿黄疸 微生态制剂 全静脉营养支持治疗 免疫功能 营养状况 

分 类 号：R722.17[医药卫生—儿科]