Metabolites isolated from Penicillium HDS-Z-1E, an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase  

作　　者：Chuan Tang Rui Gao Xiaoyuan Tang Yu Zhang Weixing Feng Baomin Feng Xuan Lu 

机构地区：[1]College of Life and Health,Dalian University,Dalian 116622,China

出　　处：《Chinese Herbal Medicines》2024年第2期227-230,共4页中草药（英文版）

基　　金：supported by Excellent Youth Team for Scientific Research,Innovation and Entre-preneurship of Dalian University(No.XQN202004)。

摘　　要：Objective:To study the compounds isolated from Penicillium HDS-Z-1E,an endophytic fungal strain isolated from Taxus cuspidata and their activation effect of catalase(CAT).Methods:The chemical constituents were isolated from Penicillium HDS-Z-1E,by using silica gel,Sephadex LH-20 and HPLC.The structural elucidations of five metabolites were elucidated on the basis of spectroscopic including 1 H-NMR,13C-NMR,HMBC and HSQC.Their activation sites of catalase have been investigated by molecular docking.Results:Five metabolites,compounds(1–5)were isolated from Penicillium HDS-Z-1E and identified as 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one(1),4-hydroxymethyl-5,6-dihydro-pyran-2-one(2),5,6-dihydro-2-oxo-2H-pyran-4-carboxylic(3),N-acetyl-hydrazinobenzoic acid(4),and methyl 2-(2,5-dihydroxyphenyl)acetate(5).Conclusion:Compound 3 is a new compound.Compounds 3 and 4 may have potential activators of catalase,providing a theoretical basis for the development of CAT activators.

关 键 词：catalase activators 5 6-dihydro-2-oxo-2H-pyran-4-carboxylic molecular simulation PENICILLIUM Taxus cuspidata Sieb.et Zucc 

分 类 号：R284[医药卫生—中药学]