术前外周血小板/淋巴细胞比值与胃癌初治患者临床病理特征及预后的相关性分析  

Correlation Between Preoperative Peripheral Platelet/Lymphocyte Ratio and Clinicopathological Features and Prognosis of Patients With Primary Gastric Cancer

作　　者：邓佳英 卢永芳[1] 汤琼健 曾富强 DENG Jiaying;LU Yongfang;TANG Qiongjian;ZENG Fuqiang(Department of Laboratory,Longyan First Hospital,Longyan Fujian 364000,China)

机构地区：[1]龙岩市第一医院检验科,福建龙岩364000

出　　处：《中国卫生标准管理》2024年第11期66-69,共4页China Health Standard Management

摘　　要：目的探讨胃癌初治患者术前外周血小板/淋巴细胞比值(platelet-lymphocyte ratio,PLR)与患者临床病理特征之间的关系,并分析对患者预后的影响。方法选择2018年1月—2019年1月在龙岩市第一医院胃肠外科科确诊并收治的285例胃癌患者,以PLR=150为基线,共有193例低PLR患者(PLR<150,设置为低PLR组),92例高PLR患者(PLR≥150,设置为高PLR组)。分别比较高低PLR组患者的各类临床病理资料以及手术后1、3、5年总生存率(overall survival,OS)和无病生存率(diseasefreesurvival,DFS),以Cox风险回归模型评估影响胃癌预后因素。结果高PLR组肿瘤浸润程度深、淋巴结转移数多、TNM分期较晚、白蛋白较低,与低PLR组相比,差异有统计学意义(P<0.05);高低PLR组1、3、5年OS及DFS对比,差异有统计学意义(P<0.05)。结论术前PLR是影响胃癌患者DFS的独立预后因素,可以为临床治疗过程中提供依据。Objective To explore the relationship between preoperative peripheral platelet/lymphocyte ratio(PLR)and clinicopathological features of patients with primary gastric cancer,and to analyze the impact on the prognosis of patients.Methods A total of 285 patients with gastric cancer diagnosed and treated in the department of gastrointestinal surgery of Longyan First Hospital from January 2018 to January 2019 were selected.Taking PLR=150 as the baseline,there were 193 patients with low PLR(PLR<150)and 92 patients with high PLR(PLR≥150).The clinicopathological data,1,3 and 5-year overall survival(OS)and disease free survival(DFS)of patients with high and low PLR groups were compared,and Cox risk regression model was used to evaluate the factors affecting the prognosis of patients with gastric cancer.Results The high PLR group had deep tumor infiltration,more lymph node metastasis,late TNM stage and low albumin,which were significantly different from the low PLR group(P<0.05).There were significant differences in OS and DFS in the high PLR group at 1,3 and 5 years(P<0.05).Conclusion preoperative PLR is an independent prognostic factor of DFS in patients with gastric cancer,which can provide basis for clinical treatment.

关 键 词：胃癌 血小板/淋巴细胞比值 临床病理 预后 PLR IL-1 VEGF 

分 类 号：R656[医药卫生—外科学]