布洛芬混悬液口服联合盐酸丁卡因胶浆外敷在隐匿性阴茎患儿术后短期镇痛的效果和安全性  

Short-term analgesic efficacy and safety of oral ibuprofen suspension combined with tetracaine hydrochloride mucilage in children after concealed penis surgery

作　　者：郭大凯 高宇 徐志刚 李晶晶 王洁 吴昌鎏 吴婷 唐建秋 Guo Dakai;Gao Yu;Xu Zhigang;Li Jingjing;Wang Jie;Wu Changliu;Wu Ting;Tang Jianqiu(Department of Urology,Guiqian International General Hospital,Guiyang City,Guizhou Province 550024,China)

机构地区：[1]贵黔国际总医院泌尿外科,贵阳市550024

出　　处：《中华疼痛学杂志》2024年第2期265-269,共5页Chinese Journal Of Painology

摘　　要：目的探讨布洛芬混悬液口服联合盐酸丁卡因胶浆外敷在隐匿性阴茎患儿术后的短期镇痛效果及安全性。方法纳入贵黔国际总医院泌尿外科2019年10月18日至2023年2月28日收治的拟行手术治疗的隐匿性阴茎患儿120例,年龄0~<18岁,按照随机数字表法将其随机分为2组,联合用药组和丁卡因外敷组,每组60例。联合用药组术后使用布洛芬混悬液口服联合盐酸丁卡因胶浆外敷镇痛,丁卡因外敷组只使用盐酸丁卡因胶浆外敷镇痛。于用药后15、30 min及1、2 h,记录视觉模拟评分(VSA),并观察不良反应发生情况。结果两组患儿不同药物起效时间例数比较,差异无统计学意义(Z=1.25,P=0.229)。组间VAS评分差异有统计学意义(F=217.10,P<0.001),各时点VAS评分差异有统计学意义(F=191.69,P<0.001),组间与时间的交互作用有统计学意义(F=39.50,P<0.001);进一步两两比较的结果显示,两组患儿用药后30 min、1 h、2 h的VAS评分差异均具有统计学意义(P均<0.05)。组别和不同BMI不存在交互作用(F=1.02,P>0.05),两组患儿镇痛时长差异有统计学意义(F=709.96,P<0.001),不同BMI间镇痛时长差异有统计学意义(F=352.44,P<0.05)。所有患儿都完成了治疗,未发现药物引起的不良反应。结论隐匿性阴茎患儿术后采用布洛芬混悬液口服联合丁卡因胶浆外敷较单独丁卡因胶浆的短期镇痛效果更好,镇痛时间更长,且未增加不良反应。Objective To explore the short-term analgesic efficacy and safety of oral ibuprofen suspension combined with tetracaine hydrochloride mucilage in children with concealed penis after surgery.Methods A total of 120 children with concealed penis,aged<18 years old,in the Department of Urology,Guiqian International General Hospital from October 18,2019 to February 28,2023,were randomly divided into two groups according to the random number table:combination group and tetracaine external application group,60 cases in each group.Ibuprofen suspension combined with tetracaine hydrochloride mucilage was used in the combination group,and only tetracaine hydrochloride mucilage was used in the tetracaine external application group.Visual analogue score(VSA)was recorded at 15,30 min and 1,2 h after the treatment,and the adverse reactions were observed.Results There was no significant difference in the onset time of drugs between the two groups(Z=1.25,P=0.229).VAS had significant differences between the two groups(F=217.10,P<0.001),at the different time points(F=191.69,P<0.001),and the interaction between group and time(F=39.50,P<0.001).The duration of analgesia had significant differences between the two groups(F=709.96,P<0.001),and the different BMI(F=352.44,P<0.05),but no interaction between group and BMI(F=1.02,P>0.05).No adverse reactions happened in all children.Conclusion The short-term analgesic efficacy of oral ibuprofen suspension combined with tetracaine mucilage is better for children after concealed penis surgery,than that of tetracaine mucilage alone,with longer analgesic time,and without adverse reactions increase.

关 键 词：布洛芬 丁卡因 隐匿性阴茎 儿童 疼痛 

分 类 号：R726.9[医药卫生—儿科]