颈椎间盘源性疼痛相关脑网络静息态功能连接研究  

Study on the resting state functional connectivity of the brain network in cervical discogenic pain

作　　者：张宏[1] 邬小平[1] 高明[1] 刘润[1] 银小辉[1] 陈松 马鸣岳[1] ZHANG Hong;WU Xiaoping;GAO Ming;LIU Run;YIN Xiaohui;CHEN Song;MA Mingyue(De partment of Radiology,the Affiliated Xian Central Hospital of Xian Jiaotong University,Xi'an 710003,China;Department of Radiology,XD Group Hospital,Xi'an 710077,China)

机构地区：[1]西安交通大学附属西安市中心医院放射科,陕西西安710003 [2]西电集团医院放射科,陕西西安710077

出　　处：《实用放射学杂志》2024年第5期693-696,共4页Journal of Practical Radiology

基　　金：陕西省重点研发计划项目(2023-YBSF-673);西安市科技计划项目(23YXYJ0004)。

摘　　要：目的探讨颈椎间盘源性疼痛(CDP)患者疼痛网络静息态功能连接的异常改变。方法收集40例CDP患者及40例年龄、性别相匹配健康对照(HC)的静息态功能磁共振成像(rs-fMRI)数据,以后岛叶(PI)为种子点定义疼痛网络并进行基于种子点的全脑功能连接分析,探讨CDP患者和HC之间的功能连接差异,并分析功能连接与临床指标之间的相关性。结果CDP患者双侧PI与双侧丘脑(THA)之间的功能连接增强,左侧PI与中扣带回(MCC)、左侧中央后回(PoCG)与MCC之间的功能连接减弱。右侧PI与左侧THA之间的功能连接与视觉模拟量表(VAS)呈正相关,左侧PoCG与MCC之间的功能连接与VAS呈负相关。结论CDP患者存在疼痛网络静息态功能连接的异常改变,为揭示CDP患者疼痛的神经病理学机制提供影像学依据。Objective To explore the abnormal changes of resting state functional connectivity of pain networks in patients with cervical discogenic pain(CDP).Methods The resting-state functional magnetic resonance imaging(rs-fMRI)data of 40 patients with CDP and 4O age-and gender-matched healthy controls(HC)were collected.The seed of posterior insula(PI)was used to define the pain network,and seed-based whole-brain functional connectivity analyses were performed to explore the difference of functional connectivity between CDP patients and HC,the associations between functional connectivity and clinical measures were analyzed.Results The functional connectivity between bilateral PI and bilateral thalamus(THA)was increased,and the functional connectivity between left PI and middle cingulate cortex(MCC),left postcentral gyrus(PoCG)and MCC were decreased in CDP patients.Moreover,the func-tional connectivity between right PI and left THA was positively correlated with visual analogue scale(VAS),and the functional connectivity between left PoCG and MCC was negatively correlated with VAS.Conclusion Functional connectivity abnormalities exist in pain network resting state of CDP patients,which may provide an imaging basis for revealing the neuropathological mechanism of pain in CDP patients.

关 键 词：颈椎间盘源性疼痛 疼痛网络 功能连接 静息态功能磁共振成像 

分 类 号：R681.5[医药卫生—骨科学] R322.85[医药卫生—外科学] R445.2[医药卫生—临床医学]