多模态MRI在眼内期视网膜母细胞瘤疗效评估中的应用  

Application of multimodal MRI in the efficacy evaluation of intraocular retinoblastoma

作　　者：李林[1] 孙志群[2] 李方元 LI Lin;SUN Zhiqun;LI Fangyuan(Medical Imaging Center,Children's Hospital Affiliated to Shandong University,Ji'nan 250022,China;Department of Neonatology,Weifang People's Hospital,Weifang,Shandong Province 261041,China;Department of Radiology,Ji'nan Southern Suburb Hospital,Ji'nan 250003,China)

机构地区：[1]山东大学附属儿童医院医学影像中心,山东济南250022 [2]潍坊市人民医院新生儿科,山东潍坊261041 [3]济南南郊医院影像科,山东济南250003

出　　处：《实用放射学杂志》2024年第5期785-788,共4页Journal of Practical Radiology

基　　金：济南市卫生健康委员会科技计划项目(2022-1-46)。

摘　　要：目的探讨多模态MRI在儿童视网膜母细胞瘤(RB)经选择性眼动脉化疗(SOAI)后疗效评估中的价值。方法收集80例单眼发病眼内期RB患儿经化疗后的MRI及临床资料,分析保眼成功与失败患儿化疗前后MRI各项参数变化。结果保眼成功患儿化疗后肿瘤最大径及信号强度增强率(△SI)较治疗前明显缩小,肿瘤与视盘距离及表观扩散系数(ADC)明显增大,钙化/瘤体比值增加,眼球大小变化不明显;保眼失败患儿化疗后肿瘤最大径及视网膜剥离范围明显增大,眼球截面积明显缩小,△SI、ADC及钙化/瘤体比值与治疗前变化不明显。结论多模态MRI能够精确评估患儿化疗效果,并为后续治疗方案的制订提供确凿依据。Objective To explore the value of multimodal MRI in evaluating the efficacy of retinoblastoma(RB)after selective ophthalmic artery infusion(SOAI)in children.Methods The MRI and clinical data of 80 children with intraocular RB with monocular disease after chemotherapy were collected.The changes of MRI parameters in children with successful and failed eye protection before and after chemotherapy was analyzed.Results After chemotherapy,the maximum tumor diameter and△SI were significantly reduced,the distance between tumor and optic disc and apparent diffusion coefficient(ADC)were significantly increased,the calcification/tumor ratio was increased,and the change of eyeball size was not obvious in the children with successful eye protection compared with before treatment.After chemotherapy,the maximum tumor diameter and the range of retinal detachment were significantly increased,and the cross-sectional area of the eyeball was significantly reduced,and△SI,ADC and calcification/tumor ratio were not significantly changed compared with before treatment in the children with failed eye protection.Conclusion Multimodal MRI can accurately evaluate the effectiveness of chemotherapy in children and provide conclusive evidence for the formulation of subsequent treatment plans.

关 键 词：多模态磁共振成像 眼内期 视网膜母细胞瘤 疗效评估 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.7[医药卫生—诊断学]