补虚止遗汤联合去氨加压素片治疗小儿遗尿症下元虚寒证40例临床观察  

Clinical observation on the combination of Buxu Zhiyi Tang(补虚止遗汤)and desmopressin tablets in the treatment of 40 cases of lower yuan deficiency cold syndrome in childrenwith enuresis

作　　者：裘晓芬 QIU Xiaofen(Department of Traditional Chinese Medicine Pediatrics,Wenzhou Integrated Traditional Chinese and Western Medicine Hospital,Wenzhou,Zhejiang,325000,China)

机构地区：[1]温州市中西医结合医院中医儿科,浙江温州325000

出　　处：《中医儿科杂志》2024年第3期64-67,共4页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：温州市基础性公益科研项目(Y20220259)。

摘　　要：目的观察补虚止遗汤联合去氨加压素片治疗小儿遗尿症下元虚寒证的临床疗效。方法选取2021年1月至2022年6月温州市中西医结合医院中医儿科门诊收治的遗尿症下元虚寒证患儿80例,按照随机数字表法分为治疗组和对照组,各40例。对照组给予去氨加压素片口服,治疗组在对照组治疗方法的基础上给予补虚止遗汤治疗。2组均1周为1个疗程,共治疗4个疗程后统计临床疗效、遗尿频率、膀胱容量、血浆抗利尿激素(ADH)水平、匹兹堡睡眠指数(PSQI)评分及不良反应发生情况。结果治疗组总有效率为95.00%(32/40),对照组为80.00%(38/40),2组比较,差异有统计学意义(P<0.05)。治疗前,2组遗尿频率、膀胱容量比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组遗尿频率明显降低,膀胱容量明显增加,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组降低或增加更显著(P<0.05)。治疗前,2组血浆ADH水平、PSQI评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组血浆ADH水平明显升高,PSQI评分明显下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高或下降更显著(P<0.05)。对照组不良反应总发生率为20.00%(8/40),治疗组为5.00%(2/40),2组比较,差异有统计学意义(P<0.05)。结论补虚止遗汤联合去氨加压素片治疗小儿遗尿症下元虚寒证,疗效显著,且无明显不良反应,值得临床推广应用。Objective To observe the clinical efficacy of Buxu Zhiyi Tang(补虚止遗汤)combined with desmopressin tablets in the treatment of lower yuan deficiency cold syndrome in children with enuresis.Methods From January 2021 to June 2022,80 children with enuresis of lower yuan deficiency cold syndrome admitted to the Traditional Chinese Medicine Pediatric Clinic of Wenzhou Integrated Traditional Chinese and Western Medicine Hospital were selected.They were randomly divided into a treatment group and a control group,with 40 cases in each group,using a random number table method.The control group was given oral administration of desmopressin tablets to the affected children,while the treatment group was treated with Buxu Zhiyi Tang on the basis of the control group's treatment method.Both groups received one course of treatment per week.After a total of four courses of treatment,clinical efficacy,enuresis frequency,bladder volume,plasma antidiuretic hormone(ADH)levels,Pittsburgh Sleep Index(PSQI)score,and incidence of adverse reactions were recorded.Results The total effective rate of the treatment group was 95.00%(32/40),while that of the control group was 80.00%(38/40).The difference between the two groups was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the frequency of enuresis and bladder capacity between the two groups(P>0.05),with comparability.After treatment,the frequency of enuresis significantly decreased and the bladder capacity significantly increased in both groups.Compared with the same group before treatment,the differences were statistically significant(P<0.05),and the treatment group showed a more significant decrease or increase(P<0.05).Before treatment,there was no statistically significant difference in plasma ADH levels and PSQI scores between the two groups(P>0.05),with comparability.After treatment,the plasma ADH levels in both groups significantly increased,and the PSQI score significantly decreased.Compared with the same group before t

关 键 词：小儿 遗尿症 下元虚寒证 补虚止遗汤 临床观察 

分 类 号：R272.6[医药卫生—中医儿科学]