徐州市与南京市三级教学医院抗菌药物使用与鲍曼不动杆菌耐亚胺培南的相关性研究  

Research on the Correlation between the Use of Antibacterial Drugs and Imipenem resistant Acinetobacter Baumannii in Tertiary Teaching Hospitals in Xuzhou and Nanjing

作　　者：刘莹 曹加[2] 许亚洲 LIU Ying;CAO Jia;XU Ya-zhou(Laboratory Department of Xuzhou Maternal and Child Health Care Hospital,Xuzhou Jiangsu 221009,China;Pharmacy Department of Jiangsu Province Hospital,Nanjing 210029,China;Pharmacy Department of Xuzhou Maternal and Child Health Care Hospital,Xuzhou Jiangsu 221009,China)

机构地区：[1]徐州市妇幼保健院检验科,江苏徐州221009 [2]江苏省人民医院药学部,南京210029 [3]徐州市妇幼保健院药事科,江苏徐州221009

出　　处：《抗感染药学》2024年第4期365-369,共5页Anti-infection Pharmacy

基　　金：江苏省研究型医院学会精益化用药-石药专项科研基金项目(编号:JY202026)。

摘　　要：目的:分析江苏省徐州市和南京市两地三级教学医院抗菌药物使用与鲍曼不动杆菌(Acinetobacter baumannii,AB)耐亚胺培南的相关性,为临床减少亚胺培南耐药鲍曼不动杆菌(imipenem-resistantAcinetobacter baumannii,IRAB)的产生提供参考。方法:收集2019年1月-2021年12月徐州市2所三级教学医院和南京市4所三级教学医院住院患者标本中所检出的15434株鲍曼不动杆菌作为研究资料,采用相关系数法和线性回归法分析3年间南京和徐州医院抗菌药物使用与IRAB产生的相关性。结果:2019年-2021年徐州和南京两地IRAB构成比均呈明显增高趋势,而碳青霉烯类、β-内酰胺类和氟喹诺酮类药物的使用分别与IRAB的构成比呈显著相关(P<0.05)。结论:减少碳青霉烯类、哌拉西林-他唑巴坦钠、氟喹诺酮类等抗菌药物使用可能有助于降低IRAB的产生。Objective:To analyze the correlation between the use of antibacterial drugs and imipenem-resistant Acinetobacter Baumannii in tertiary teaching hospitals in Xuzhou and Nanjing,Jiangsu Province,and to provide reference for clinical reduction of imipenem-resistant Acinetobacter baumannii(IRAB).Methods:A total of 15434 strains of Acinetobacter baumannii detected from inpatient specimen from two tertiary teaching hospitals in Xuzhou and four tertiary teaching hospitals in Nanjing from January 2019 to December 2021 were used as the research objects,and the correlation between the use of antibacterial drugs and IRAB in hospitals of Nanjing and Xuzhou in three years was analyzed using the correlation coefficient method and linear regression method.Results:From 2019 to 2021,the composition ratio of IRAB in Xuzhou and Nanjing showed a significant increase trend,while the use of carbapenems,β-lactams and fluoroquinolones was significantly related to the composition ratio of IRAB(P<0.05).Conclusion:Reducing the use of carbapenems,piperacillin tazobactam sodium,fluoroquinolones and other antibacterial drugs may help to reduce IRAB.

关 键 词：抗菌药物使用 亚胺培南耐药鲍曼不动杆菌 相关性 

分 类 号：R915[医药卫生—微生物与生化药学] R978.1[医药卫生—药学]