电针辅助药物治疗社交恐惧症的疗效观察及对预后的影响  

Observation of the therapeutic effect of electroacupuncture combined with medication on social phobia and its influence on prognosis

作　　者：张新宇 杨柳 武长继 ZHANG Xinyu;YANG Liu;WU ChangJi(Shalingzi Hospital of Zhangjiakou,Hebei,Zhangjiakou 075000,China)

机构地区：[1]河北省张家口市沙岭子医院,张家口075000

出　　处：《上海针灸杂志》2024年第6期621-626,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：张家口市科学技术研究与发展计划项目(1821101D)。

摘　　要：目的观察电针辅助帕罗西汀和舒必利治疗社交恐惧症的临床疗效及对神经电生理和预后的影响。方法将90例社交恐惧症患者用随机数字表法分为试验组和对照组,每组45例。两组均采取心理疏导,对照组予口服帕罗西汀和舒必利治疗,试验组在对照组药物治疗基础上另予电针治疗。比较两组临床疗效和不良反应发生情况,观察两组治疗前后神经电生理指标(MMN波幅、MMN潜伏期和N2靶潜伏期)、自主神经功能指标[RR间期平均值标准差(SDANN)、相邻两正常窦性RR间期差值50 ms个数所占百分率(PNN50)和相邻RR间期差值的均方根(RMSSD)]、Liebowitz社交焦虑量表(Liebowitz social anxiety scale,LSAS)评分、自评焦虑量表(self-rating anxiety scale,SAS)评分以及生活质量综合评定问卷(generic quality of life inventory-74,GQOLI-74)评分的变化。结果试验组总有效率高于对照组,组间差异具有统计学意义(P<0.05)。治疗1个月后和治疗后,试验组MMN潜伏期、N2靶潜伏期、LSAS评分和SAS评分低于对照组,MMN波幅及SDANN、RMSSD和PNN50高于对照组(P<0.05);治疗后,试验组躯体功能、心理功能、社会功能和物质生活评分高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论电针辅助帕罗西汀和舒必利治疗社交恐惧症的疗效优于单纯药物治疗,可改善临床症状,调节神经电生理和自主神经功能,改善预后。Objective To observe the clinical efficacy of electroacupuncture combined with Paroxetine and Sulpiride in the treatment of social phobia and its influence on neuroelectrophysiology and prognosis.Method Ninety patients with social phobia were randomly divided into a trial group and a control group,with 45 cases in each group.Both groups were given psychological counseling.The control group was treated with Paroxetine and Sulpiride,and the trial group was treated with electroacupuncture in addition to the medication of the control group.The clinical efficacy and adverse reactions were compared between the two groups.The electrophysiological indexes(MMN amplitude,MMN latency and N2 target latency),autonomic nerve function indexes[standard deviation of the mean RR interval(SDANN),the percentage of the number of neighbouring normal sinus RR intervals with a 50-ms difference(PNN50)and root mean square of the differences between successive RR intervals(RMSSD)],Liebowitz social anxiety scale(LSAS)score,self-rating anxiety scale(SAS)score and generic quality of life inventory-74(GQOLI-74)score were observed before and after treatment in the two groups.Result The total effective rate of the trial group was higher than that of the control group,the difference between the two groups was statistically significant(P<0.05).After 1 month of treatment and after treatment,the MMN latency,N2 target latency,LSAS score and SAS score of thetrial group were lower than those of the control group,and the MMN amplitude and SDANN,RMSSD and PNN50 were higher than those of the control group(P<0.05);after treatment,the scores of somatic functioning,psychological functioning,social functioning and material life of the trial group were higher than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion The efficacy of electroacupuncture combined with Paroxetine and Sulpiride in the treatment of social phobia is better than that of drug

关 键 词：针刺疗法 电针 针药并用 恐惧症 社交 焦虑 预后 神经电生理 

分 类 号：R246.6[医药卫生—针灸推拿学]