布拉氏酵母菌联合维生素D对反复呼吸道感染并发腹泻儿童的辅助治疗作用  

Adjunctive Therapeutic Effect of Saccharomyces Boulardii Combined with Vitamin D on Children with Recurrent Respiratory Tract Infections and Diarrhea

作　　者：丁玉海 DING Yuhai(Jinta County People's Hospital,Jiuquan 735399,Gansu Province,China)

机构地区：[1]酒泉市金塔县人民医院,甘肃酒泉735300

出　　处：《中国实用乡村医生杂志》2024年第4期50-52,56,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的探讨布拉氏酵母菌联合维生素D对反复呼吸道感染(repeated respiratory tract infection,RRTI)并发腹泻小儿的辅助治疗作用。方法本研究病例来源于酒泉市金塔县人民医院2021年1月—2022年12月收治的小儿RRTI并发腹泻病例,样本总量为100例。依据随机化分组原则将100例患儿分为对照组和研究组各50例。两组患儿入院后根据药敏试验结果调整抗生素选择,对照组加用蒙脱石散治疗腹泻;研究组加用布拉氏酵母菌散和维生素D滴剂进行口服。比较两组患儿治疗后的住院恢复情况、治疗8周后的免疫改善情况和出院1年后的呼吸道感染复发情况。结果两组患儿各症状持续时间差异有统计学意义(P<0.05)。治疗8周后,两组患儿CD4、CD8、CD4/CD8、IgA、IgG水平差异有统计学意义(P<0.05)。随访1年后,两组患儿呼吸道感染复发频次差异有统计学意义(P<0.05)。结论布拉氏酵母菌和维生素D治疗小儿RRTI并发腹泻,能够进一步加快症状缓解,提高免疫功能和减少肺部感染复发。Objective To investigate the adjunctive therapeutic effect of Saccharomyces boulardii combined with vitamin D on children with recurrent respiratory tract infection(RRTI)and diarrhea.Methods This study was conducted on 100 cases of pediatric RRTI complicated with diarrhea admitted to Jinta County People's Hospital in Jiuquan City from January 2021 to December 2022.According to the principle of randomization,100 pediatric patients were divided into a control group and a study group,with 50 cases in each group.After admission,the two groups of children adjusted their choice of antibiotics according to the results of drug sensitivity test.The control group added montmorillonite powder to treat diarrhea,and the study group added Saccharomyces boulardii powder and vitamin D drops for oral administration additionally.The hospital recovery after treatment,the immune improvement after 8 weeks of treatment and the recurrence of respiratory tract infection after 1 year of discharge were compared between the two groups.Results There was a significant difference in the duration of each symptom between the two groups(P<0.05).After 8 weeks of treatment,there were significant differences in CD4,CD8,CD4/CD8,IgA and IgG levels between the two groups(P<0.05).After one year of follow-up,there was a significant difference in the frequency of recurrent respiratory infections between the two groups(P<0.05).Conclusion The treatment of diarrhea caused by RRTI with Saccharomyces boulardii and vitamin D can further accelerate symptom relief,improve immune function,and reduce the recurrence of lung infections in children.

关 键 词：反复呼吸道感染 腹泻 小儿 布拉氏酵母菌 维生素D 蒙脱石散 

分 类 号：R725.6[医药卫生—儿科]