微量泵持续泵入与静脉滴注小剂量胰岛素治疗糖尿病酮症酸中毒疗效对比  

Comparison between Continuous Micro-Pump Infusion and Intravenous Infusion of Small Dose Insulin in the Treatment of Diabetes Ketoacidosis

作　　者：洪慧贞 HONG Huizhen(Zhangzhou City Hospital,Zhangzhou 363119,Fujian Province,China)

机构地区：[1]漳州市医院,福建漳州363119

出　　处：《中国实用乡村医生杂志》2024年第4期74-76,共3页Chinese Practical Journal of Rural Doctor

摘　　要：目的比较微量泵持续泵入与静脉注射小剂量胰岛素治疗糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)的效果。方法选择2021年10月—2023年3月漳州市医院收治的DKA患者90例,以随机数字表法分为对照组和观察组各45例。两组均接受小剂量胰岛素治疗,对照组给药途径为静脉滴注;而观察组给药途径为微量泵持续泵入,比较两组患者的治疗效果及不良反应。结果观察组血糖达标时间、尿酮体转阴时间及血pH值恢复时间短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖低于对照组,差异有统计学意义(P<0.05);观察组丙二醛水平低于对照组,而超氧化物歧化酶水平高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.44%,低于对照组的22.22%,差异有统计学意义(P<0.05)。结论采用微量泵持续泵入胰岛素治疗DKA,能够改善临床相关指标,降低血糖水平,改善应激反应指标,减少不良反应发生。Objective To compare the efficacy of continuous micro pump infusion and intravenous small dose insulin injection in the treatment of diabetes ketoacidosis(DKA).Methods Ninety DKA patients who admitted in Zhangzhou City Hospital from October 2021 to March 2023 were selected and divided into a control group and an observation group by random number table method,with 45 cases in each group.Both groups received low-dose insulin treatment.The control group received intravenous infusion,while the observation group received continuous infusion with a micro-pump.The treatment efficacy and adverse reactions between two groups of patients were compared.Results The time for blood glucose to reach the standard,urine ketone body to turn negative and blood pH recovery in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the fasting plasma glucose and 2-hour postprandial blood glucose in the observation group were lower than those in the control group(P<0.05).The malondialdehyde in the observation group was lower than that in the control group,while the superoxide dismutase was higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.44%,which was lower than the control group’s 22.22%(P<0.05).Conclusion The use of a micro-pump to continuously pump insulin to treat DKA could improve clinical related indicators,lower blood sugar levels,improve stress response indicators,and reduce the occurrence of adverse reactions.

关 键 词：微量泵 静脉注射 胰岛素 小剂量 糖尿病 酮症酸中毒 

分 类 号：R589.1[医药卫生—内分泌]