Analysis of The Correlation Between inhA Gene Mutation and Resistance to Protionamide in Drug-Resistant Mycobacterium Tuberculosis  

作　　者：Xulin Huang Tian Zheng Shutao Li 

机构地区：[1]Xinjiang Uygur Autonomous Region Infectious Disease Hospital(Sixth People’s Hospital of the Autonomous Region),Urumqi 830063,China [2]The Eighth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China

出　　处：《Journal of Clinical and Nursing Research》2024年第4期132-136,共5页临床护理研究（英文）

基　　金：Study on the Correlation Between inhA Gene Mutation of Multidrug-Resistant MTB and Resistance to Protionamide (Project number: 2022013)。

摘　　要：Objective: To investigate the characteristics of katG and inhA gene mutations in multidrug-resistant tuberculosis (MDR-TB), pre-extensively drug-resistant tuberculosis (preXDR-TB), and their correlation with resistance to protionamide (Pto). Methods: A total of 229 patients with MDR-TB and pre-XDR-TB diagnosed in the Eighth Affiliated Hospital of Xinjiang Medical University from January 2020 to February 2024 were selected to analyze the characteristics of katG and inhA mutations in MTB clinical isolates and their correlation with Pto resistance. Results: The mutation rate of katG (with or without inhA mutation) was 85.2%. The mutation rates in MDR-TB and pre-XDR-TB were 87.4% (125/143) and 81.4% (70/86), respectively. The mutation rate of inhA (including katG mutation) was 14.8% (34/229), which was 12.6% (18/143) and 18.6% (16/86) in MDR-TB and pre-XDR-MTB, respectively. There was no difference in mutation (P > 0.05). Conclusion: The total resistance rate to Pto in 229 strains was 8.7% (20/229), which was 8.4% (12/143) and 9.3% (8/86) in MDR-TB and pre-XDR-TB, respectively. Among the inhA mutant strains, 13 were resistant to the Pto phenotype, and the resistance rate was 65% (13/20). In MDR-TB and pre-XDR-TB strains resistant to Pto, inhA gene mutations occurred in 66.7% (6/9) and 63.6% (7/11), respectively. The resistance rates of MDR-MTB and pre-XDR-TB strains without inhA gene mutation to Pto were 2.4% (3/125) and 5.7% (4/70), respectively.

关 键 词：TUBERCULOSIS Anti-multiple drug resistance Prothionamide GENE MUTATIONS 

分 类 号：R52[医药卫生—内科学]