不同炮制方法对大皂角和猪牙皂中油类成分的影响  

Effects of different processing methods on oil components in Gleditsiae sinensis Fructus and Gleditsiae Fructus Abnormalis

作　　者：豆市蓉 曹彦刚 李凯[1,2,3] 田连起 孟祥乐[1,4] 石延榜[1] 张丽先[5] 李红伟 冯卫生[1] DOU Shi-rong;CAO Yan-gang;LI Kai;TIAN Lian-qi;MENG Xiang-le;SHI Yan-bang;ZHANG Li-xian;LI Hong-wei;FENG Wei-sheng(Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry of Yu-Yao,Zhengzhou 450046,China;Henan Provincial Research Center for Special Processing Technology of Chinese Medicines,Zhengzhou 450046,China;The First Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou 450003,China;Henan Napu Biotechnology Co.,Ltd.,Zhengzhou 450002,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]豫药全产业链研发河南省协同创新中心,河南郑州450046 [3]河南省中药特色炮制技术工程研究中心,河南郑州450046 [4]河南中医药大学第一附属医院,河南郑州450003 [5]河南省纳普生物技术有限公司,河南郑州450002

出　　处：《中成药》2024年第6期1809-1818,共10页Chinese Traditional Patent Medicine

基　　金：河南省科技攻关(232102311214);河南省自然科学基金项目(242300420427);河南省科技研发计划联合基金项目(优势学科培育类)(232301420073)。

摘　　要：目的考察炒制、酥制、炒炭对大皂角和猪牙皂中油类成分的影响。方法水蒸气蒸馏法提取挥发油,索氏提取法提取脂肪油,测定提取率。GC-MS法分析油类成分种类和相对含量,进行聚类分析。结果炮制后,2种药材中脂肪油提取率升高,挥发油提取率(除酥制外)降低;大皂角中油类成分提取率高于猪牙皂;有毒烯烃苯类成分相对含量降低。结论大皂角和猪牙皂中油类成分种类和相对含量存在明显差异,前者药用品质更优,其减缓燥烈之性的炮制机理可能是降低有毒烯烃苯类成分相对含量。AIM To investigate the effects of stir-frying,processing with butter and carbonizing by stir-frying on oil components in Gleditsiae sinensis Fructus and Gleditsiae Fructus Abnormalis.METHODS The volatile oils and fatty oils were extracted by steam distillation method and Soxhlet extraction method,respectively,after which the extraction rates were determined.GC-MS was applied to analyzing the kinds and relative contents of oil components,after which cluster analysis was performed.RESULTS After the processing,the two medicinal materials demonstrated increased extraction rates of fatty oils and decreased extraction rates of volatile oils(except for processing with butter),the extraction rates of oil components in Gleditsiae sinensis Fructus were higher than those in Gleditsiae Fructus Abnormalis,and the reduced relative contents of toxic olefin benzene components were observable.CONCLUSION The kinds and relative contents of oil components in Gleditsiae sinensis Fructus and Gleditsiae Fructus Abnormalis exist obvious differences,the former displays better medicinal quality,whose processing mechanism in alleviating dryness and strength may contribute to the reduction of relative contents of toxic olefin benzene components.

关 键 词：大皂角 猪牙皂 脂肪油 挥发油 炮制方法 GC-MS 聚类分析 

分 类 号：R283[医药卫生—中药学]