高选择性邻氯硝基苯的合成研究  

Study on Synthesis of High Selectivity 2-Chloronitrobenzene

作　　者：杨镭 徐小兵 王震宇 吴祥 朱成峰 李有桂 YANG Lei;XU Xiao-bing;WANG Zhen-yu;WU Xiang;ZHU Cheng-feng;LI You-gui(Anhui Dongzhi Guangxin Agrochemical Co.Ltd.,Dongzhi 247260,China;Anhui Provincial Key Laboratory of Green Manufacturing in the Phosgene Industry,Guangde 242200,China;School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei 230009,China)

机构地区：[1]安徽东至广信农化有限公司,安徽东至247260 [2]光气产业绿色制造安徽省重点实验室,安徽广德242200 [3]合肥工业大学化学与化工学院,安徽合肥230009

出　　处：《安徽化工》2024年第3期68-70,共3页Anhui Chemical Industry

摘　　要：以氯苯为起始原料,在SO42-/2Al2O3-ZrO2固体酸的催化下与硝酸反应获得硝基氯苯混合物,分离纯化后得到邻氯硝基苯,通过NMR对合成的目标产物进行了表征和确证。对合成路线进行了优化,合成邻氯硝基苯的最优路线:氯苯(1.0 eq.)、硝酸(1.1 eq.)、催化剂(0.1 w/w),反应温度25℃和反应时间1.0 h,邻硝基氯苯与对硝基氯苯质量比约为1∶1,收率约为70.2%。Using chlorobenzene with nitric acid under the solid acid catalyst of SO42-/2Al2O3-ZrO2 to synthesis of nitrochlorobenzene.After separation and purification obtained 2-nitrochlorobenzene which was characterized by NMR.At the same time,optimized the synthetic route,and the optimized result were chlorobenzene(1.0 eq.),nitric acid(1.1 eq.),catalyst(0.1 w/w),reaction temperature 25℃and reaction time 1.0 h,the ratio of o-nitrochlorobenzene to pnitrochlorobenzene was about 1∶1 and the yield was about 70.2%.

关 键 词：氯苯 硝化 邻氯硝基苯 合成 

分 类 号：TQ253.2[化学工程—有机化工]