有氧糖酵解在乳腺癌中的作用及中医药干预研究进展  

Role of Aerobic Glycolysis in Breast Cancer and Traditional Chinese Medicine Intervention:A Review

作　　者：邓显光 阮慧 李恋 范洪桥[2] 刘丽芳[2] DENG Xianguang;RUAN Hui;LI Lian;FAN Hongqiao;LIU Lifang(The First Clinical College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学第一中医临床学院,长沙410208 [2]湖南中医药大学第一附属医院,长沙410007

出　　处：《中国实验方剂学杂志》2024年第13期219-229,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金青年科学基金项目(82205128);湖南省“十四五”第一批中医药领军人才培养项目(湘中医药综合处便函[2022]5号);湖南省研究生科研创新项目(CX20230811);湖南中医药大学“实验动物科普”专项(2023DWKP13)。

摘　　要：乳腺癌已经成为发病率最高的恶性肿瘤,尽管目前新兴药物的出现为乳腺癌患者延长了总生存,但由于肿瘤异质性、耐药性等原因还是拥有较高的复发转移率。葡萄糖为乳腺癌细胞能量代谢的主要来源,而乳腺癌细胞的葡萄糖代谢与正常乳腺细胞有着明显区别,乳腺癌细胞的高能量需求和快速生长使得他们对于葡萄糖的需求远超正常细胞,更重要的是,即使在有氧条件下,乳腺癌细胞的糖酵解效应也会明显增强,以满足乳腺癌细胞的高能量代谢需求。造成乳腺癌细胞糖酵解效应增强的主要原因是细胞中糖酵解相关酶及调节因子活性的增强,主要包括了丙酮酸激酶、己糖激酶、磷酸果糖激酶、乳酸脱氢酶和葡萄糖转运蛋白,通过干预这些酶和调节因子的活性,可以调节乳腺癌细胞糖酵解代谢进程,从而抑制乳腺癌的增殖、促进凋亡、逆转耐药和侵袭转移等。中医药治疗乳腺癌历史悠久,在抗复发转移、耐药等方面取得了重大成绩,近年来中医药单体、单味中药、复方干预乳腺癌有氧糖酵解的相关研究越来越多,且取得了较大的成绩,大量体内外实验均显示有氧糖酵解是中医药治疗乳腺癌的重要潜在靶点,但目前缺乏全面的综述总结。基于此,该文详细阐述了关键靶点在有氧糖酵解和乳腺癌中的作用,以及中医药通过干预糖酵解治疗乳腺癌的相关研究进行归纳总结,以期为进一步研究提供新的思路。Breast cancer has become the malignant tumor with the highest incidence rate.Although the emergence of new drugs has prolonged the overall survival of breast cancer patients,it still possesses a high recurrence and metastasis rate due to tumor heterogeneity and drug resistance.Glucose is the main source of energy metabolism for breast cancer cells,and the glucose metabolism of breast cancer cells is significantly different from that of normal breast cells.The high energy demand and rapid growth of breast cancer cells make their demand for glucose much higher than that of normal cells.Moreover,even under aerobic conditions,the glycolytic effect of breast cancer cells will be significantly enhanced to meet the high energy metabolism demand of breast cancer cells.The main reason for the enhanced glycolytic effect of breast cancer cells is the enhanced activity of glycolysis-related enzymes and regulatory factors,including pyruvate kinase,hexokinase,phosphofructokinase,lactate dehydrogenase,and glucose transporter protein.The metabolism process of glycolysis in breast cancer cells can be regulated by interfering with the activity of these enzymes and regulatory factors,thus inhibiting the proliferation of breast cancer,promoting apoptosis,and reversing drug resistance,invasion,and metastasis.Traditional Chinese medicine(TCM)has a long history of treating breast cancer and has made significant achievements in the aspects of anti-recurrence,metastasis,and drug resistance.In recent years,more and more research related to the intervention of aerobic glycolysis in breast cancer by TCM monomers,single-flavored TCM,and compounds has been conducted and has made great achievements.In addition,a large number of in vivo and in vitro experiments have shown that aerobic glycolysis is an important potential target for the treatment of breast cancer by TCM,but there is a lack of a comprehensive review and summary.On this basis,this paper elaborated on the roles of key targets in aerobic glycolysis and breast cancer and summarized t

关 键 词：乳腺癌 有氧糖酵解 瓦博格效应 中医药 

分 类 号：R2-0[医药卫生—中医学] R22R242R285.5