橙皮苷及其衍生物抗癌作用机制的研究进展  

Anticancer Mechanism of Hesperidin and Its Derivatives: A Review

作　　者：田秀蓉 王昊[1,3] 于鹏龙[2] 吕世盟 李勇华 蒋祥林[2] 杨勤[2] 吕武宾[4] 刘霞[2] 马月香 TIAN Xiurong;WANG Hao;YU Penglong;LYU Shimeng;LI Yonghua;JIANG Xianglin;YANG Qin;LYU Wubin;LIU Xia;MA Yuexiang(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Chongqing Three Gorges Medical College,Chongqing 404120,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;The People's Hospital Affiliated to Chongqing Three Gorges Medical College,Chongqing 404120,China)

机构地区：[1]山东中医药大学,济南250355 [2]重庆三峡医药高等专科学校,重庆404120 [3]中国中医科学院中医临床基础医学研究所,北京100700 [4]重庆三峡医药高等专科学校附属人民医院,重庆404120

出　　处：《中国实验方剂学杂志》2024年第13期259-270,共12页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重庆市中医药重点学科中医基础理论建设项目(渝中医[2021]16号);重庆市教育委员科学技术研究项目(KJQN202302702,KJQN202002707,KJQN202102708);全国基层名老中医药专家工作室建设项目(国中医药人教函[2021]44号);重庆三峡医药高等专科学校校级自然课题(XJ2023002302)。

摘　　要：该文通过检索中国知网、万方、PubMed等电子数据库,回顾过去10年发表的关于橙皮苷预防及治疗癌症的相关文献,总结了橙皮苷抗癌机制的研究进展。橙皮苷的药理作用十分广泛,具有抗炎、抗氧化、抗菌、抗病毒、抗癌、调节免疫力、抗辐射、神经保护、心血管保护等作用。其抗癌机制主要包括抑制癌细胞增殖、促进癌细胞凋亡、减少血管生成、抑制癌细胞侵袭和迁移、调节免疫与自噬、抗炎抗氧化。这种多方面的抗癌机制使橙皮苷对多种癌症显示出化学预防和治疗效果,使其成为一种广谱抗癌药。该文还总结了橙皮苷与顺铂、阿霉素、环磷酰胺、紫杉醇4种抗癌药合用的效果,发现橙皮苷能增强这些抗癌药对癌细胞的增殖抑制作用,还能降低耐药性和不良反应。由于橙皮苷水溶性较差,生物利用度不高,临床使用受到一定限制,因此还总结了目前通过结构修饰或与其他化学物质、纳米载药制剂组合获得的衍生物来提高其生物利用度的方法。发现橙皮苷的衍生物既保留了橙皮苷的抗癌疗效,又有效克服了橙皮苷水溶性差、生物利用率低等缺陷,很好地预测了橙皮苷及其衍生物具备的良好应用前景。This article reviews relevant literature on the prevention and treatment of cancer with hesperidin published in the past 10 years by searching electronic databases such as China National Knowledge Infrastructure(CNKI),Wanfang,and PubMed,and summarizes the research progress on the anticancer mechanism of hesperidin.Hesperidin has a wide range of pharmacological effects,including anti-inflammatory,antioxidant,antibacterial,antiviral,anticancer,immune-regulatory,anti-radiation,neuroprotective and cardiovascular protective properties and so on.Its anticancer mechanisms mainly include inhibiting cancer cell proliferation,promoting apoptosis,reducing angiogenesis,inhibiting invasion and migration of cancer cells,regulating immunity and autophagy,and exerting antioxidant and anti-inflammatory effects.As a broad-spectrum anticancer drug,hesperidin manifests chemo-preventive and therapeutic effects across various cancers,contingent upon its multifaceted anticancer mechanisms.Furthermore,this article summarizes the synergistic effects of hesperidin in combination with cisplatin,doxorubicin,cyclophosphamide and paclitaxel.It elucidates that hesperidin can enhance the cytotoxicity of these anticancer drugs against cancer cells while mitigating drug resistance and adverse side effects.Nonetheless,the clinical use is somewhat constrained due to its poor water solubility and limited bioavailability.Therefore,this article also outlines the current strategies for enhancing hesperidin's bioavailability,including structural modification,combination with other chemical substances,and utilization of nano drug carriers.The discovery of derivatives of hesperidin not only preserves the anticancer efficacy of hesperidin,but also effectively overcomes the shortcomings of poor water solubility and low bioavailability of hesperidin,effectively predicting the good application prospects of hesperidin and its derivatives.

关 键 词：橙皮苷 衍生物 抗癌 作用机制 研究进展 

分 类 号：R284.2[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24