枸骨的化学成分及其药理活性研究进展  

Research progress on chemical constituents and pharmacological activities of Ilex cornuta

作　　者：宋钰 纪丽莲 刘艳丽[2] 王桃云[1] SONG Yu;JI Li-lian;LIU Yan-li;WANG Tao-yun(School of Chemistry and Life Sciences,Suzhou University of Science and Technology,Suzhou 215009,China;College of Pharmaceutical Sciences,Soochow University,Suzhou 215127,China)

机构地区：[1]苏州科技大学化学与生命科学学院,苏州215009 [2]苏州大学药学院,苏州215127

出　　处：《天然产物研究与开发》2024年第6期1082-1099,共18页Natural Product Research and Development

基　　金：国家自然科学基金面上项目(82073912)。

摘　　要：枸骨(Ilex cornuta)为冬青科冬青属常绿灌木或小乔木,是我国传统中药之一,其叶子常被瑶胞聚居区当作“苦丁茶”的来源。枸骨的化学成分是其药理活性的基础,主要包括三萜皂苷类、黄酮类、多酚类、生物碱类和挥发油类等,近10年共鉴定出278种单体成分。现代药理学研究表明,枸骨具有抗氧化、抗菌、抗炎及抗肿瘤等多种活性。本研究对近10年国内外有关枸骨化学成分、提取与检测方法、药理活性及作用机制的研究报道进行了总结,并对枸骨研究的不足及未来研究发展方向进行了探讨,旨在为枸骨的进一步研究与应用提供参考。Ilex cornuta is an evergreen shrub or dungarung of genus Ilex in Aquifoliaceae family.It is one of the traditional Chinese medicines in China.The leaves of I.cornuta are often used as the source of“Kudingcha”by Yao ethnic group.The chemical constituents of I.cornuta are the basis of its pharmacological activity.It mainly includes triterpenoidal saponins,flavonoids,polyphenols,alkaloids and volatile oils.A total of 278 monomer components have been identified in the past ten years.Modern pharmacological studies have shown that I.cornuta has antioxidant,antibacterial,anti-inflammatory,anti-tumor activities,and so on.This research summarized the reports on the chemical constituents,extraction and detection methods,pharmacological activities and mechanisms of action of I.cornuta at home and abroad in the past ten years.Drawbacks of current researches and development directions were also discussed,aiming to provide reference for further research and application of I.cornuta.

关 键 词：枸骨 化学成分 药理活性 作用机制 提取与检测 

分 类 号：R285[医药卫生—中药学]