糖尿病患者睑板腺功能障碍病理机制的研究进展  

Research progress on the pathological mechanism of meibomian gland dysfunction in diabetic patients

作　　者：韩怡泽 李科军[1] 马清敏[1] 樊芳[1] 唐稳稳 程静 晏林伟 王亚峰 Han Yize;Li Kejun;Ma Qingmin;Fan Fang;Tang Wenwen;Cheng Jing;Yan Linwei;Wang Yafeng(Department of Ophthalmology,Hebei General Hospital,Shijiazhuang 050051,Hebei Province,China;Hebei Medical University,Shijiazhuang 050017,Hebei Province,China;North China University of Science and Technology,Tangshan 063210,Hebei Province,China)

机构地区：[1]河北省人民医院眼科,河北省石家庄市050051 [2]河北医科大学,河北省石家庄市050017 [3]华北理工大学,河北省唐山市063210

出　　处：《国际眼科杂志》2024年第7期1098-1101,共4页International Eye Science

摘　　要：睑板腺功能障碍是一种以睑板腺终末导管阻塞和(或)睑酯分泌的质或量异常为主要特征的慢性、弥漫性睑板腺病变,临床上可引起泪膜异常和眼表炎症反应,从而导致眼部刺激症状,严重时可能损伤角膜从而影响视功能。睑板腺功能障碍可分为睑酯低排出型和高排出型,低排出型又进一步分为腺泡萎缩型和阻塞型。随着对糖尿病研究的进展,发现在糖尿病早期,患者的睑板腺组织即受到慢性损伤,导致其结构和功能均发生变化,糖尿病患者睑板腺功能障碍的发病率更高,程度更严重。而引起糖尿病患者睑板腺功能障碍的因素很多而且复杂,目前机制并不是很清楚,文章就国内外学者对糖尿病睑板腺功能障碍病理机制的研究进展作一综述。Meibomian gland dysfunction is a chronic and diffuse disease of the meibomian glands,characterized by obstruction and(or)abnormal secretion of the terminal ducts.Clinically,it can lead to tear film abnormalities and inflammation of the ocular surface,resulting in symptoms of ocular irritation and potential corneal damage that may impact visual function.Meibomian gland dysfunction can be classified into two types based on meibomian gland secretion:low secretion type and high secretion type.The low secretion type further includes acinar atrophy type and obstruction type.In recent years,research has revealed that patients with diabetes experience chronic damage to their meibomian gland tissue in the early stages of the disease,leading to structural and functional changes.The incidence and severity of meibomian gland dysfunction are higher in diabetic patients.However,there are numerous complex factors contributing to this condition in diabetes patients,and mechanisms remain unclear at present.This article reviews both domestic and international research progress on the pathological mechanism underlying meibomian gland dysfunction in diabetes.

关 键 词：睑板腺功能障碍 糖尿病 病理机制 

分 类 号：R587.1[医药卫生—内分泌] R777.13[医药卫生—内科学]