外周血cfDNA液体活检技术在肝棘球蚴病诊治中的应用进展  

Application of peripheral blood cfDNA liquid biopsy in diagnosis and treatment of hepatic echinococcosis

作　　者：杨智義 赵成俊 胡欣芫 潘佰猛 张秋雨 张挽乾 曹芮 张灵强[1] Yang Zhiyi;Zhao Chengjun;Hu Xinyuan;Pan Baimeng;Zhang Qiuyu;Zhang Wanqian;Cao Rui;Zhang Lingqiang(Department of Hepatobiliary and Pancreatic Surgery,Qinghai University Affiliated Hospital,Xining 810000,China)

机构地区：[1]青海大学附属医院肝胆胰外科,西宁810000

出　　处：《中华肝脏外科手术学电子杂志》2024年第3期389-393,共5页Chinese Journal of Hepatic Surgery(Electronic Edition)

基　　金：中科院兰州分院“西部之光”项目。

摘　　要：循环游离DNA(cfDNA)是主要存在于血液以及其他体液的核酸片段,包括细胞核DNA和线粒体DNA。cfDNA作为一种“液体活检”技术,在肝棘球蚴病的诊断、预后和疗效监测等方面均有重要的应用价值,有望成为新一代的肝棘球蚴病诊治新方法。Circulating cell-free DNA (cfDNA) is a nucleic acid fragment mainly existing in blood and other body fluids,including nuclear DNA and mitochondrial DNA.As a "liquid biopsy" technique,cfDNA has high application value in the diagnosis,prognosis and clinical efficacy monitoring of hepatic echinococcosis,which is expected to become a new-generation diagnosis and treatment approach for hepatic echinococcosis.

关 键 词：cfDNA 棘球蚴病 肝 液体活检 高通量测序(NGS) 诊断 疗效监测 

分 类 号：R532.32[医药卫生—内科学]