膀胱结石啮齿类动物模型的制备方法及应用进展  

Methods to establish bladder calculi models in rodents and their applications:a review

作　　者：陈丽芬 许丽[1] 孙祖越[1] CHEN Lifen;XU Li;SUN Zuyue(NHC Key Laboratory of Reproduction Regulation,Shanghai Engineering Research Center of Reproductive Health Drug and Devices,Shanghai Institute for Biomedical and Pharmaceutical Technologies,National Evaluation Center for Toxicology of Fertility Regulating Drugs,Shanghai 200237,China)

机构地区：[1]国家卫生健康委员会生育调节药械重点实验室,上海生殖健康药具工程技术研究中心,上海市生物医药技术研究院,中国生育调节药物毒理检测中心,上海200237

出　　处：《中国药理学与毒理学杂志》2024年第6期455-461,共7页Chinese Journal of Pharmacology and Toxicology

摘　　要：膀胱结石是一种泌尿系统疾病,多源于地理环境、饮食习惯、种族遗传及各种尿路疾病等。为研究其发生机制、开发治疗药物并寻找防治措施,有必要建立或改进膀胱结石实验动物模型。膀胱结石实验动物模型的制备方法共有4类:物理诱导、化学诱导、微生物诱导和基因敲除。本综述对膀胱结石啮齿类实验动物模型制备方法、特征和优缺点进行归类总结,重点介绍模型的制备流程、周期和有效性,并比较其特点,指出现有模型在药物研发应用中存在的问题,以期为防治膀胱结石疾病药械的非临床有效性及安全性研究提供参考。Bladder calculi is a type of urinary calculi,which is mostly due to geographical environ⁃ments,dietary habits,ethnic genetics and diseases of the urinary tract.It is necessary to establish or improve animal models of bladder calculi in order to research the mechanism and develop drugs for the disease.There are 4 types of construction methods for bladder calculi models,which are physical induction,chemical induction,microbial induction and gene knockout models.This review classifies and summarizes the construction methods,characteristics,advantages and disadvantages of rodent ani⁃mal models for bladder calculi,focusing on the construction processes,cycles and effectiveness.Differ⁃ent models were compared and problems with the application of present models in drug research and development were pointed out in order to provide reference for the non-clinical effectiveness and safety studies of drugs and devices for the prevention and treatment of bladder calculi.

关 键 词：膀胱结石 啮齿类 动物模型 诱导 

分 类 号：R96[医药卫生—药理学]