QCT骨密度测定对应用SGLT-2抑制剂的老年糖尿病患者骨质疏松和预后的评估  

QCT Bone Mineral Density Measurement in Evaluation of Osteoporosis and Prognosis of EIderly Diabetic Patients Treated with SGLT-2 Inhibitors

作　　者：赵宇洁 肖童[1] 王丽 ZHAO Yuyjie;XIAO Tong;WANG Li(Department of Endocrinology and Geriatrics,He'nan Chest Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省胸科医院内分泌与老年病科,河南郑州450003

出　　处：《临床医学工程》2024年第6期663-664,共2页Clinical Medicine & Engineering

摘　　要：目的探讨定量CT(QCT)骨密度(BMD)测定在评估SGLT-2抑制剂治疗的老年糖尿病患者骨质疏松及预后中的应用价值。方法选取2018年1月至2022年6月我院收治的老年糖尿病患者100例,根据是否使用SGLT-2抑制剂分为SGLT-2组和非SGLT-2组,比较两组的BMD,比较SGLT-2组中不同预后患者的BMD。结果SGLT-2组治疗后的L_(1)、L_(2)、L_(3)、L_(1)~L_(3)BMD与治疗前对比无显著差异(P>0.05)。SGLT-2组与非SGLT-2组治疗后的L_(1)、L_(2)、L_(3)、L_(1)~L_(3)BMD对比无显著差异(P>0.05)。SGLT-2组中,预后不良患者的L_(1)、L_(2)、L_(3)、L_(1)~L_(3)BMD均显著低于预后良好患者(P<0.05)。结论SCLT-2抑制剂对老年糖尿病患者的BMD影响可能较轻,利用QCT测量BMD可及早发现患者骨质疏松及骨折的潜在风险,可用于预后评估。Objective To explore the application value of bone mineral density(BMD)detected by quantitative CT(QCT)in evaluating osteoporosis and prognosis of elderly diabetic patients treated with SGLT-2 inhibitors.Methods A total of 100 elderly diabetic patients admitted to our hospital from January 2018 to June 2022 were selected and divided into the SGLT-2 group and non-SGLT-2 group according to whether SGLT-2 inhibitors were used.The BMD was compared between the two groups,and the BMD was compared between patients with different prognosis in SGLT-2 group.Results The comparison of L_(1),L_(2),L_(3)and L_(1)~L_(3)BMD before and after treatment showed no significant difference in SGLT-2 group(P>0.05).No significant difference was found in BMD of L_(1),L_(2),L_(3)and L_(1)~L_(3)after treatment between the SGLT-2 group and the non-SGLT-2 group(P>0.05).In SGLT-2 group,the BMD of L_(1),L_(2),L_(3),and L_(1)~L_(3)in patients with poor prognosis were significantly lower than those in patients with good prognosis(P<0.05).Conclusions The impact of SCLT-2 inhibitors on BMD in elderly patients with diabetes may be mild.The use of QCT to measure BMD can early detect the potential risk of osteoporosis and fracture of patients,and can be used for prognostic evaluation.

关 键 词：定量CT 糖尿病 SGLT-2抑制剂 骨质疏松 预后 

分 类 号：R587.2[医药卫生—内分泌]