3.0T超导磁共振成像和单核细胞与高密度脂蛋白比值、成纤维细胞生长因子与糖尿病周围神经病变的关系  

Relationships between 3.0T superconducting MRI,FGF21,MHR and DPN

作　　者：张梅[1] 马燕 马娟 王伟[1] Zhang Mei;Ma Yan;Ma Juan;Wang Wei(Department of Medical Imaging,Traditional Chinese Medical Hospital of Xinjiang Urgur Autonomous Regions,Affiliated Traditional Chinese Medical Hospital of Xinjiang Medical University,Urumuqi 830000,China;Department of Medical Imaging,Xinjiang Shihezi Oasis Hospital,Shihezi 832000,China)

机构地区：[1]新疆医科大学附属中医医院医学影像科,乌鲁木齐830000 [2]新疆石河子绿洲医院医学影像科,石河子832000

出　　处：《中国医学装备》2024年第6期67-71,共5页China Medical Equipment

基　　金：新疆维吾尔自治区自然科学基金(2022D01C168)。

摘　　要：目的:探究3.0T超导磁共振成像(MRI)及成纤维细胞生长因子(FGF21)、单核细胞/高密度脂蛋白比值(MHR)与糖尿病周围神经病变(DPN)的相关性。方法:选取2021年1月至2022年12月新疆医科大学附属中医医院诊治的80例2型糖尿病(T2DM)患者,根据是否合并DPN将其分为DPN组(44例)和非DPN(NDPN)组(36例)。两组均采用3.0T超导MRI行磁共振(MR)扩散张量成像技术检查,通过酶联免疫吸附试验(ELISA)检测血清FGF21、MHR水平。比较两组MR扩散张量成像检查参数中视神经各向异性分数(FA)、平均弥散系数(MD)、平行扩散系数(λ_(∥))及垂直扩散系数(λ_(⊥))值,以及血清FGF21、MHR水平差异。采用Spearman秩相关分析探究MR弥散张量成像参数及FGF21、MHR与DPN的相关性。结果:两组患者的性别、体质量指数(BMI)比较,差异无统计学意义(P>0.05),DPN组患者的年龄、病程均显著高于NDPN组,差异有统计学意义(t=5.039、7.852,P<0.05),FA值显著低于NDPN组,MD、λ_(∥)及λ_(⊥)值显著高于NDPN组,差异有统计学意义(t=8.934、10.459、12.233、4.640,P<0.05);DPN组血清FGF21、MHR水平显著高于NDPN组,差异有统计学意义(t=3.286、24.509,P<0.05)。Spearman秩相关性结果显示,患者的年龄、病程、MD、λ_(∥)、λ_(⊥)值、FGF21及MHR水平与DPN呈显著正相关(r=0.458、0.666、0.836、0.799、0.445、0.282、0.864,P<0.05),FA与DPN呈显著负相关(r=-0.753,P<0.05)。结论:MR弥散张量成像相关参数及FGF21、MHR水平均与DPN存在显著相关性,且患者的年龄、病程也与DPN的发生有关,需引起临床的重视。Objective:To explore the correlation between 3.0T superconducting magnetic resonance imaging(MRI),fibroblast growth factor 21(FGF21),monocyte to high density lipoprotein ratio(MHR)and diabetes peripheral neuropathy(DPN).Methods:A total of 80 patients with type 2 diabetes mellitus(T2DM)who were diagnosed and treated in Affiliated Traditional Chinese Medical Hospital of Xinjiang Medical University from January 2021 to December 2022 were selected as the study objects,and they were divided into DPN group(44 cases)and non-diabetic peripheral neuropathy(NDPN group)(36 cases)according to whether combined with DPN.Both two groups adopted 3.0T superconducting MRI to undergo examination by using the technique of magnetic resonance(MR)diffusion tensor imaging,and the enzyme-linked immunosorbent assay(ELISA)was used to detect serum FGF21 and MHR levels.The differences of fractional anisotropy(FA)of optical nerve,mean diffusivity(MD),maximum eigenvalue(λ_(∥)),middle eigenvalue(λ_(⊥)),serum FGF21 and MHR levels of the detection parameters of MR diffusion tensor imaging between two groups were compared.Spearman rank correlation analysis was adopted to explore the correlation between the parameters of MR diffusion tensor imaging and the levels of serum FGF21,MHR and DPN.Results:There were not statistically significant differences in gender and body mass index(BMI)between the two groups(P>0.05),while the age and course of disease in the DPN group were significantly higher than those in the NDPN group,with a statistically significant differences(t=5.039,7.852,P<0.05),respectively.The FA value of the DPN group was significantly lower than that of the NDPN group,and the MD,λ_(∥),λ_(⊥)values of the DPN group were significantly higher than those of the NDPN group(t=8.934,10.459,12.233,4.640,P<0.05),respectively.The serum levels of FGF21 and MHR in the DPN group were significantly higher than those in the NDPN group(t=3.286,24.509,P<0.05),respectively.Spearman correlation results showed that age,course of disease,MD value,�

关 键 词：MR弥散张量成像 成纤维细胞生长因子(FGF21) 单核细胞与高密度脂蛋白比值(MHR) 糖尿病周围神经病变(DPN) 2型糖尿病(T2DM) 相关性 

分 类 号：R445.2[医药卫生—影像医学与核医学]