水滑石负载Lewis酸催化Knoevenagel反应合成巴比妥酸衍生物  

Knoevenagel Condensation Catalyzed by Hydrotalcite Supported Lewis Acid to the Synthesis of Barbituric Acid Derivatives

作　　者：明郑敏 伍静 孙韵辰 程果 刘心韵 Ming Zhengmin;Wu Jing;Sun Yunchen;Cheng Guo;Liu Xinyun(School of Pharmacy,Guizhou Medical University,Guiyang 561113,China)

机构地区：[1]贵州医科大学药学院,贵州贵阳561113

出　　处：《山东化工》2024年第10期24-26,共3页Shandong Chemical Industry

基　　金：2022年国家级大学生创新创业训练计划项目资助(项目编号:202210660132)。

摘　　要：水滑石(LDH)负载Lewis酸催化剂作为一种绿色高效环境友好的新型负载催化剂,可极大提升Knoevenagel缩合反应的反应速率、缩短反应时间并减少后处理步骤。水滑石是一类具有天然层状结构的阴离子型主客体层状结构化合物,具有酸碱性、层板上离子可交换性等特点,是Lewis酸的良好载体,可负载不同的Lewis酸制备负载催化剂催化Knoevenagel缩合反应。实验结果表明,以水滑石负载氯化铝(LDH/AlCl_(3))为催化剂,无水乙醇为溶剂,苯甲醛与巴比妥酸的物质的量之比为1∶1时,在75℃条件下反应30 min合成5-亚苄基巴比妥酸的产率可达98.3%。LDH负载Lewis酸催化剂可高效催化Knoevenagel缩合反应合成一系列巴比妥酸衍生物,反应条件温和,操作简便,产率较高,具有一定的工业化应用前景。As a novel green,efficient and environmentally friendly loaded catalyst,the hydrotalcite(LDH)-loaded Lewis acid catalyst greatly improves reaction rate,shortens reaction time and reduces work-up steps of Knoevenagel condensation reaction.LDH is a class of anionic host-guest lamellar compounds with natural lamellar structure,which has the characteristics of acid-base and ion-exchangeability on the lamellae,and it can be loaded with different Lewis acids to prepare loaded catalysts to catalyze the Knoevenagel condensation reaction.The experimental results showed that with LDH/AlCl_(3) as catalyst,anhydrous ethanol as solvent,and benzaldehyde and barbituric acid in the ratio of 1:1,the synthesis of 5-benzylidenebarbituric acid was achieved in a yield of up to 98.3%within 30 min at 75℃.Thecatalystsfor theLDH-loaded Lewisacid catalyzed the condensation reaction of Knoevenagel in a highly efficient way.A series of barbituric acid derivatives were synthesized using the developed method.The protocol feature mild reaction conditions,simple operation,high yield,environmental friendliness,as well as prospects for industrialization.

关 键 词：水滑石 巴比妥酸衍生物 负载催化剂 路易斯酸 KNOEVENAGEL缩合反应 

分 类 号：TQ426.92[化学工程] O621.3[理学—有机化学]