光甘草定-白藜芦醇-虎杖苷组合物的协同美白抗氧抗炎活性  

Synergistic Whitening,Antioxidant and Anti-Inflammatory Activities of Glabridin,Resveratrol and Poldatin Complex

作　　者：黄洁 谢翀 潘志 李楚忠 陈庆生 龚盛昭 黄亚东[1] HUANG Jie;XIE Chong;PAN Zhi;LI Chuzhong;CHEN Qingsheng;GONG Shengzhao;HUANG Yadong(College of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong,China;Guangzhou Uniasia Cosmetic Technology Co.,Ltd.,Guangzhou 510663,Guangdong,China;Guangdong Industry Technical College,Guangzhou 510300,Guangdong,China)

机构地区：[1]暨南大学生命科学技术学院,广东广州510632 [2]环亚化妆品科技有限公司研究院,广东广州510663 [3]广东轻工职业技术学院,广东广州510300

出　　处：《香料香精化妆品》2024年第3期99-107,233,共10页Flavour Fragrance Cosmetics

摘　　要：围绕体外美白相关功效,对10种美白成分进行了功效对比,并从中优选出强功效成分进行组合筛选,发现了由虎杖苷、白藜芦醇、光甘草定构成的组合物具备较强美白效果,即使在较低浓度0.0001μmol/L,该组合物可显著抑制细胞内黑色素生成(抑制率19.47%)及酪氨酸酶活性(抑制率23.7%),同时表现出较强自由基清除能力,DPPH的IC50为0.3445 mmol/L,羟自由基的IC50为19.82 mmol/L。另外,该组合物具备一定抗炎活性,可抑制一氧化氮(NO)和肿瘤坏死因子(TNFα)的生成,并显著下调小眼畸形相关转录因子(MITF)通路相关基因表达。为其在化妆品类中的应用提供了理论依据。Based on the related phenotype of skin pigmentation,we screened 10 common whitening ingredients and its combinations,and it was found that a composition of polydatin,resveratrol and glabridin showed high efficiency in antipigmentation.Even at low concentration of 0.0001μmol/L,this composition could significantly inhibit melanogenesis and tyrosinase activity with inhibition rates of 19.47%and 23.7%respectively.Meanwhile,this composition exhibited higher antioxidation and anti-inflammation than single ingredient,which improved DPPH(IC500.3445 mmol/L)and hydroxy(IC5019.82 mmol/L)scavenging activity,and inhibited the production of inflammatory factors,like NO and TNFα.This composition could also significantly down-regulated the expression of MITF related genes.This study provided a theoretical basis for its application in cosmetics.

关 键 词：美白 黑色素 酪氨酸酶 虎杖苷 白藜芦醇 光甘草定 小眼畸形相关转录因子(MITF) 

分 类 号：TQ658[化学工程—精细化工]