仿生细胞膜介导的白藜芦醇包合物的制备与表征  

Preparation and Characterization of Resveratrol Inclusion Complexes Mediated by Biomimetic Cell Membranes

作　　者：冯艳菊 李孟婕 程伟峰 FENG Yanju;LI Mengjie;CHENG Weifeng(Shanghai Qiran Biotechnology Co.,Ltd.,Shanghai 201702,China;Shanghai Jinjia Technology Co.,Ltd.,Shanghai 201210,China;Shanghai OLI Enterprises Co.,Ltd.,Shanghai 201401,China)

机构地区：[1]上海其然生物科技有限公司,上海201702 [2]上海缙嘉科技有限公司,上海201210 [3]上海奥利实业有限公司,上海201401

出　　处：《香料香精化妆品》2024年第3期128-134,共7页Flavour Fragrance Cosmetics

摘　　要：以磺丁基-β-环糊精(SBE-β-CD)为壁材,同时复配具有仿生细胞膜结构的聚季铵盐-51(PQ-51),制备白藜芦醇/磺丁基-β-环糊精/PQ-51(RES-SBE-β-CD-PQ-51)包合物。通过红外光谱、扫描电子显微镜对包合物的微观构象进行表征,以高效液相色谱法进行测定。结果表明,白藜芦醇(resveratrol,RES)被成功包合于SBE-β-CD-PQ-51中,包合后RES的溶解度、变色情况及热稳定性均得到改善。相较于RES-SBE-β-CD,PQ-51的加入使RES的包封率由90.0%提高至99.2%,负载量由6.8%提高至7.9%,溶解度由2267倍提高至3160倍,变色情况进一步减缓,同时提高了细胞安全性。The RES-SBE-β-CD-PQ-51 inclusion compound was prepared by using sulfobutyl-β-cyclodextrin(SBE-β-CD)as wall material and polyquaternary ammonium salt(PQ-51)with bionic cell membrane structure.The microscopic conformation of the inclusion compound was characterized by infrared spectroscopy and scanning electron microscopy.HPLC was used for determination.The results showed that RES was successfully incorporated into SBE-β-CD-PQ-51,and the solubility,discoloration and thermal stability of RES were improved after inclusion.Compared with RES-SBE-β-CD,the addition of PQ-51 increased the encapsulation rate of RES from 90.0% to 99.2%,the drug load from 6.8%to 7.9%,the solubility from 2267 times to 3160 times,the discoloration was further reduced and the cytotoxicity of resveratrol was decreased,and also the cell safety was improved.

关 键 词：白藜芦醇 聚季铵盐-51 磺丁基-β-环糊精 包合物 

分 类 号：TQ658[化学工程—精细化工]