仿生皮脂脂质体OriginalSL^(TM)的开发与皮肤屏障修复效果评估  

Development and Evaluation of Biomimetic Sebum Liposomes(OriginalSL^(TM))for Enhanced Skin Barrier Repair

作　　者：孙静 卢永杰 耿林 刘艳红 张兵 张炽坚 罗莹 姜乃生 SUN Jing;LU Yongjie;GENG Lin;LIU Yanhong;ZHANG Bing;ZHANG Chijian;LUO Ying;JIANG Naisheng(Hua An Tang Biotech Group,Guangzhou 628214,Guangdong,China;School of Material Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China)

机构地区：[1]花安堂生物科技集团有限公司,广东广州511400 [2]北京科技大学材料科学与工程学院,北京100083

出　　处：《香料香精化妆品》2024年第3期155-162,共8页Flavour Fragrance Cosmetics

基　　金：国家自然科学基金项目(编号52073025)。

摘　　要：旨在通过模拟人体皮肤细胞间脂质的组成和配比,开发一种仿生皮脂脂质体(OriginalSL^(TM))。该脂质体通过纳米包裹技术共包裹神经酰胺、胆固醇和白池花(Limnanthes alba)籽油,以模拟皮肤自然分泌的皮脂。结果表明,OriginalSL^(TM)为寡层脂质结构,其平均粒径为(170.2±2.3)nm,PDI值为0.02,包封率为98.0%,且在体积分数≤2.5%时无明显细胞毒性,细胞安全性良好。在3D表皮皮肤模型中,相较于单一神经酰胺或白池花籽油脂质体,OriginalSL^(TM)具有更好的保湿和修复功效,具有良好的应用价值。This study aims to mimic the composition and ratio of lipids between human skin cells by developing a biomimetic sebum liposome,namely OriginalSL^(TM).This newly developed liposome encapsulated ceramides,cholesterol,and meadowfoam seed oil to mimic natural sebum using the nanoencapsulation technology.The results indicated that OriginalSL^(TM)had an oligolamellar lipid structure,with an average particle size of(170.2±2.3)nm,a PDI value of 0.02,and an encapsulation efficiency of 98.0%.These liposomes showed no obvious cytotoxicity when the concentration less than 2.5%(in volume fraction),indicating good cellular safety.In the 3D epidermal skin model,the OriginalSL^(TM)showed better moisturizing and skin repair efficacy compared to liposomes containing only ceramide or meadowfoam seed oil,which has good potential for barrier repairing of sensitive skin.

关 键 词：仿生皮脂 皮肤屏障修复 脂质体 神经酰胺 白池花(Limnanthes alba)籽油 

分 类 号：TQ658[化学工程—精细化工]