细胞外囊泡在系统性红斑狼疮中的研究新进展  

Role of extracellular vesicles in treatment of systemic lupus erythematosus

作　　者：赵盈 刁波 杨莹莹 刘亚轩 ZHAO Ying;DIAO Bo;YANG Yingying;LIU Yaxuan(Department of Respiratory and Critical Care Medi-cine,General Hospital of Central Theater Command,Wuhan 430070,China;Medical College of Wuhan Univer-sity of Science and Technology,Wuhan 430065,China;Basic Medical Laboratory,General Hospital of Central Theater Command,Wuhan 430070,China;Hubei Key Laboratory of Central Nervous System Tumor and Interven-tion,Wuhan 430070,China)

机构地区：[1]中部战区总医院呼吸与危重症医学科,武汉430070 [2]武汉科技大学医学院,武汉430065 [3]中部战区总医院基础医学实验室,武汉430070 [4]中枢神经系统肿瘤发生与干预湖北省重点实验室,武汉430070

出　　处：《中国免疫学杂志》2024年第6期1307-1314,共8页Chinese Journal of Immunology

基　　金：湖北省卫生健康委员会科研项目(WJ2019M263)。

摘　　要：系统性红斑狼疮(SLE)是一种影响多个器官的异质性自身免疫性疾病。几乎所有细胞都能释放细胞外囊泡(EVs),包括外泌体、微粒和凋亡小体,携带核酸、蛋白质和脂质,在细胞通信中起着至关重要的作用。在SLE中,EVs可以作为自身佐剂增强免疫复合物的形成和维持炎症状态。本文综述了EVs的生物起源、在细胞通信中的信使作用,并重点介绍了EVs在SLE中免疫调节、发病机制方面的研究进展。Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disease that affects multiple organs.Extracel-lular vesicles(EVs),including exosomes,microparticles and apoptotic bodies,are released by most types of cells and carry nucleic acids,proteins and lipids,which play a crucial role in communication among cells.In SLE,extracellular vesicles can act as autoadju-vants to enhance the formation of immune complexes and maintain inflammatory states.In this review,the biological origin and mes-senger role of EVs in cell communication are reviewed,and the research progress of EVs in immune regulation and pathogenesis in SLE is highlighted.

关 键 词：系统性红斑狼疮 细胞外囊泡 外泌体 微粒 凋亡小体 

分 类 号：R593.24[医药卫生—内科学]