B细胞抗原表位鉴定方法的研究进展  

Advances on research of B-cell epitopes mapping methods

作　　者：伍春平 尹苗 陈希文 WU Chunping;YIN Miao;CHEN Xiwen(Sichuan Province Engineering Research Center for Pig Major Epidemic Disease Monitoring and Control,Mianyang 621000,China)

机构地区：[1]四川生猪重大疫病监测与防控工程研究中心,绵阳621000

出　　处：《中国免疫学杂志》2024年第6期1329-1334,共6页Chinese Journal of Immunology

基　　金：四川省重点研发项目(2023YFN0045)。

摘　　要：抗原表位是抗原决定其抗原性的基础,是诱导机体产生免疫应答的最小功能单位。B细胞抗原表位研究对于新型疫苗和治疗性药物的研发以及诊断试剂的开发具有重要意义。本文总结了近几年应用B细胞抗原表位研究的技术,并分析了各种技术的优缺点。Epitopes are the basis of antigenicity and the smallest functional unit to induce immune response.Identification of B-cell epitopes is of great significance for the development of new vaccines and therapeutic drugs as well as diagnostic reagents.In this paper,the methods applied in the study of B-cell epitopes mapping in recent years are reviewed and their advantages and shortages are analyzed.

关 键 词：B细胞抗原表位 免疫 筛选鉴定 

分 类 号：S852.43[农业科学—基础兽医学]