氯法齐明临床应用研究进展  

Research progress in clinical application of clofazimine

作　　者：吴雪娇 樊浩 彭江丽 李婧炜 杨雪婷[3] WU Xuejiao;FAN Hao;PENG Jiangli;LI Jingwei;YANG Xueting(College of Pharmacy,Dali University,Dali 671000,China;Kunming Third People′s Hospital,Kunming 650041,China;Pharmacy Department,The First People’s Hospital of Yunnan Province/the Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]昆明市第三人民医院药剂科,云南昆明650041 [3]云南省第一人民医院/昆明理工大学附属医院药学部,云南昆明650032

出　　处：《沈阳药科大学学报》2024年第6期789-796,共8页Journal of Shenyang Pharmaceutical University

基　　金：云南省中青年学术带头人后备人才计划(2019HBA4);云南省万人计划(YNWR-QNBJ-2019-104);云南省教育厅科学研究基金资助项目(2021J0381);昆明市科技计划项目(2019-1-S-25318000001154)。

摘　　要：氯法齐明(clofazimine, CFZ)是一种亚胺酚嗪类药物,从麻风病到非结核分枝杆菌疾病,具有广泛的抗菌活性。CFZ具有良好的药代动力学特征、剂量依赖性副作用和较低的价格等优点,现已成为一大研究热点。现代临床研究发现其在皮肤病、口腔炎、寄生虫、病毒以及肿瘤中也具有较好疗效。作者综述了CFZ的临床应用新进展和不良反应,总结了CFZ目前在治疗中的地位以及未来临床应用的可能方向,为临床用药提供参考。Objective Clofazimine(CFZ)is an imiphenazine,which has a wide range of antibacterial activities from leprosy to non-tuberculous mycobacterial diseases.CFZ has become a research hotspot due to its good pharmacokinetic characteristics,dose-dependent side effects and low price.Modern clinical studies have found that it also has good efficacy in skin diseases,stomatitis,parasites,viruses and tumors.The article reviews the recent progress and adverse reactions of CFZ in clinical application,summarizes the current status of CFZ in treatment and the possible direction of future clinical application,so as to provide reference for clinical medication.

关 键 词：氯法齐明 临床应用 不良反应 研究进展 

分 类 号：R5953[医药卫生—内科学]