HGI、β2-MG、HMGB1在2型糖尿病视网膜病变早期诊断中的临床价值  

The clinical value of HGI, β2-MG and HMGB1 in the early diagnosis of type 2 diabetic retinopathy

作　　者：胡贺松 张红岩 闫亚凯 刘克 乔慧子 Hu Hesong;Zhang Hongyan;Yan Yakai(Internal Medicine,Funan County Hospital of Traditional Chinese Medicine affiliated to West Anhui Health Vocational College,Fuyang 236300,China)

机构地区：[1]皖西卫生职业学院附属阜南县中医院内科,阜阳236300 [2]山东第一医科大学附属滨州人民医院 [3]阜阳职业技术学院

出　　处：《中华保健医学杂志》2024年第3期340-343,共4页Chinese Journal of Health Care and Medicine

基　　金：安徽高校自然科学研究项目(No:KJ2020A0941)。

摘　　要：目的 探讨糖化血红蛋白变异指数(HGI)、血清β2微球蛋白(β2-MG)及高迁移族蛋白B1(HMGB1)在2型糖尿病视网膜病变(DR)早期诊断中的临床价值。方法 回顾性选取2020年1月~2023年1月在皖西卫生职业学院附属阜南县中医院治疗的2型糖尿病(T2DM)合并DR患者112例作为观察组,同时选取同期在本院治疗的单纯T2DM患者54例作为对照组,比较两组患者一般资料及HGI、β2-MG、HMGB1水平,多元logistic回归模型分析影响T2DM患者并发DR的危险因素,绘制受试者工作特征(ROC)曲线,分析HGI、β2-MG、HMGB1三者单独及联合检测对T2DM患者并发DR的诊断效能。结果 观察组合并高血压占比率高于对照组,差异有统计学意义(χ^(2)=5.372,P<0.05);观察组T2DM病程、FPG、HbA1c、LDL-C、HGI、β2-MG、HMGB1水平均高于对照组,差异均有统计学意义(t=5.303、2.711、3.135、2.391、14.958、11.028、5.695,P<0.05)。多元logistic回归分析显示,合并高血压、HbA1c、HGI、β2-MG、HMGB1为影响T2DM患者并发DR的危险因素(P<0.05);ROC曲线结果显示,HGI、β2-MG、HMGB1单独T2DM患者并发DR的曲线下面积(AUC)分别为0.822、0.785、0.753,而三者联合检测的AUC为0.909,高于单一检测(P<0.05)。结论 相较于单纯T2DM患者,合并DR的T2DM患者的HGI、β2-MG、HMGB1水平异常升高,且上述指标均为DR发生的危险因素,通过联合检测三者水平对DR具有较好的诊断效能。Objective To investigate the clinical value of glycosylated hemoglobin variation index(HGI),serumβ2-microglobulin(β2-MG)and high mobility group protein B1(HMGB1)in the early diagnosis of type 2 diabetic retinopathy(DR).Methods A total of 112 patients with type 2 diabetes mellitus(T2DM)complicated with DR who were treated in Funan County Hospital of Traditional Chinese Medicine affiliated to West Anhui Health Vocational College from January 2020 to January 2023 were retrospectively selected as the study group,and 54 patients with simple T2 DM who were treated in the hospital during the same period were selected as the control group.The general data and the levels of HGI,β2-MG and HMGB1 were compared between the two groups.Multivariate logistic regression model was used to analyze the risk factors affecting DR in patients with T2 DM,and the receiver operating characteristic(ROC)curve was drawn.The diagnostic efficacy of HGI,β2-MG and HMGB1 alone and combined detection in T2DM patients with DR was analyzed.Results The proportion of hypertension in the study group was significantly higher than that in the control group(χ^(2)=5.372,P<0.05).The duration of T2 DM,FPG,HbA1 c,LDL-C,HGI,β2-MG and HMGB1 levels in the study group were higher than those in the control group,and the differences were statistically significant(t=5.303,2.711,3.135,2.391,14.958,11.028,5.695,P<0.05).Multivariate logistic regression analysis showed that hypertension,HbA1 c,HGI,β2-MG and HMGB1 were risk factors for DR in patients with T2 DM(P<0.05).The result of ROC curve showed that the area under the curve(AUC)of DR in T2 DM patients with HGI,β2-MG and HMGB1 alone was 0.822,0.785 and 0.753,respectively,while the AUC of combined detection was 0.909,which was higher than that of single detection(P<0.05).Conclusion Levels of HGI,β2-MG and HMGB1 in T2 DM are elevated in T2DM patients with DR compared to those with simple T2DM,and these indicators are risk factors for DR.Combined detection of the three levels has good diagnostic efficacy for DR

关 键 词：糖化血红蛋白变异指数 Β2微球蛋白 高迁移族蛋白B1 糖尿病视网膜病变 早期诊断 

分 类 号：R587[医药卫生—内分泌]