漯河地区人群配对受体Siglec-5/14基因多态性与COPD疾病易感性的关联研究  

Study on the association between polymorphism of paired receptor Siglec-5/14 gene and susceptibility to COPD disease in central and southern Henan

作　　者：曹娟 韩会娜 杨艳兵[1] 李森森[1,2] CAO Juan;HAN Huina;YANG Yanbing;LI Sensen(Luohe Central Hospital,Luohe 462300,China;School of Medicine,Huanghuai University,Zhumadian 463000,China)

机构地区：[1]漯河市中心医院,河南漯河462300 [2]黄淮学院医学院,河南驻马店463000

出　　处：《延安大学学报（医学科学版）》2024年第2期20-24,共5页Journal of Yan'an University:Medical Science Edition

基　　金：河南省医学科技攻关项目(LHGJ20200890);河南省科技攻关项目(222102310510)。

摘　　要：目的 分析漯河地区慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)人群Siglec-5/14基因多态性与疾病易感性的关联性。方法 采用病例-对照(COPD患者300人,健康对照者300人)研究,应用目标区域重测序结合多重PCR和高通量测序技术对两组人群Siglec-5/14等位基因进行分析,并比较各等位基因频率。结果 在男性人群中,rs883552 G/G基因型、rs7359936 C/C基因型在COPD患者中的频率高于健康对照组(OR=1.695,95%CI:1.016~2.827,P<0.05;OR=1.739,95%CI:1.047~2.890,P<0.05),吸烟人群COPD患病人群rs7359936 C/C基因型比例高于健康对照组(OR=1.821,95%CI:1.034~3.207,P<0.05)。结论 在漯河地区男性人群中,rs883552 G/G基因型、rs7359936 C/C基因型与COPD风险的增加具有相关性;在吸烟人群中,rs7359936 C/C基因型同样增加COPD患病的风险。Objective To analyze the association between Siglec-5/14 gene polymorphism and disease susceptibility in chronic obstructive pulmonary disease(COPD) population in central and southern Henan.Methods In a casecontrol study(300 COPD patients and 300 healthy controls),the Siglec-5/14 alleles of the two groups were analyzed by target region resequencing combines multiple PCR and high-throughput sequencing techniques technology,and the frequencies of alleles were compared.Results In male population,the frequency of rs883552 G/G genotype and rs7359936 C/C genotype in COPD patients were higher than those in healthy control group(OR=1.695,95% CI:1.016~2.827,P<0.05;OR=1.739,95% CI:1.047~2.890,P<0.05),the proportion of rs7359936 C/C genotype in smokers with COPD was higher than that in healthy control group(OR=1.821,95% CI:1.034~3.207,P<0.05).Conclusion In male population in central and southern Henan,rs883552 G/G genotype and rs7359936 C/C genotype are correlated with the increased risk of COPD.Among smokers,rs7359936 C/C genotype also increases the risk of COPD.

关 键 词：慢性阻塞性肺疾病 Siglec-5/14 基因频率 

分 类 号：R563[医药卫生—呼吸系统]